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Butyrate inhibits interleukin-17 and generates Tregs to ameliorate colorectal colitis in rats 期刊论文

编号：

a5ed0190-8087-4c15-b210-86512c0f273e
作者：

Zhang, Mingming^[1,2] Zhou, Qian^[3] Dorfman, Robert G.^[5] Huang, Xiaoli^[6] Fan, Tingting^[4] Zhang, Hao^[7] Zhang, Jun^[2] Yu, Chenggong^[1]
语种：

English
期刊：

BMC GASTROENTEROLOGY ISSN：1471-230X 2016 年 16 卷 ; JUL 30
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关键词：

Butyrate Inflammatory bowel disease Cytokines Th17 Treg
摘要：

Background: Butyrate is an energy source for colonocytes that is formed by bacterial fermentation of dietary fiber in the colon and that exerts broad anti-inflammatory activities. Although the administration of butyrate improves homeostasis in patients and ameliorates IBD (Inflammatory Bowel Disease)-related lesions and symptoms, the anti-inflammatory mechanisms of butyrate still remain unclear. To explore the impact of butyrate on Treg (Regulatory T cell)/Th17 (T helper 17 cell) differentiation and colitis in rats. Methods: The effect of butyrate on the expression of markers related to both Tregs and Th17 cells were determined in human monocytes as well as a rat model of colitis induced by 2,4,6-trinitrobenzene sulfonic acid. Rats were treated with butyrate in vivo, whereas the rat splenocytes and human monocytes were treated in vitro. Results: We found that butyrate administration increased peripheral blood Treg cell levels as well as plasma levels of anti-Th17 cytokines (IL-10 and IL-12). Butyrate administration further suppressed IL-17 levels in both plasma and colonic mucosa, and ameliorated colonic colitis lesions in rats. This promotion of Treg activity and inhibition of IL-17 release was also observed in human venous monocytes and rat splenocytes in vitro. Conclusions: Our results suggest that butyrate plays a key role in regulating the Treg/Th17 balance and ultimately protects the colon mucosa against the development of IBD.
推荐引用方式
GB/T 7714：

Zhang Mingming,Zhou Qian,Dorfman Robert G., et al. Butyrate inhibits interleukin-17 and generates Tregs to ameliorate colorectal colitis in rats [J].BMC GASTROENTEROLOGY,2016,16.
APA：

Zhang Mingming,Zhou Qian,Dorfman Robert G.,Huang Xiaoli,&Yu Chenggong.(2016).Butyrate inhibits interleukin-17 and generates Tregs to ameliorate colorectal colitis in rats .BMC GASTROENTEROLOGY,16.
MLA：

Zhang Mingming, et al. "Butyrate inhibits interleukin-17 and generates Tregs to ameliorate colorectal colitis in rats" .BMC GASTROENTEROLOGY 16(2016).

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