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MicroRNA-141 promotes the proliferation of non-small cell lung cancer cells by regulating expression of PHLPP1 and PHLPP2 期刊论文

编号：

a79bc6ed-4b79-4ab9-aba7-fd8c1a0f3e92
作者：

Mei, Zhoufang(梅周芳)#^[1]He, Yanchao(何燕超)^[1]Feng, Jingjing^[1];Shi, Jindong^[1];Du, Yong^[1];Qian, Ling^[1];Huang, Qihui(黄琦慧)^[1]Jie, Zhijun^[1];
语种：

English
期刊：

FEBS LETTERS ISSN：1873-3468 2014 年 588 卷 17 期 (3055 - 3061) ; AUG 25
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关键词：

MicroRNA-141 PH domain leucine-rich-repeats protein phosphatase 1 PH domain leucine-rich-repeats protein phosphatase 2 Non-small cell lung cancer Proliferation
摘要：

The dysregulation of microRNAs (miRNAs) is crucially implicated in the development of various cancers. In this study, we explored the biological role of miR-141 in non-small cell lung cancer (NSCLC). miR-141 expression was significantly up-regulated in NSCLC tissues, and its overexpression accelerated NSCLC cell proliferation in vitro and tumor growth in vivo. We subsequently identified the antagonists of PI3K/AKT signaling, PH domain leucine-rich-repeats protein phosphatase 1 (PHLPP1) and PHLPP2, as direct targets of miR-141. Re-introduction of PHLPP1 and PHLPP2 abrogated miR-141-induced proliferation of NSCLC cells. Together, the results of this study suggest that miR-141 and its targets PHLPP1 and PHLPP2 play critical roles in NSCLC tumorigenesis, and provide potential therapeutic targets for NSCLC treatment. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
推荐引用方式
GB/T 7714：

Mei Zhoufang,He Yanchao,Feng Jingjing, et al. MicroRNA-141 promotes the proliferation of non-small cell lung cancer cells by regulating expression of PHLPP1 and PHLPP2 [J].FEBS LETTERS,2014,588(17):3055-3061.
APA：

Mei Zhoufang,He Yanchao,Feng Jingjing,Shi Jindong,&Jie Zhijun.(2014).MicroRNA-141 promotes the proliferation of non-small cell lung cancer cells by regulating expression of PHLPP1 and PHLPP2 .FEBS LETTERS,588(17):3055-3061.
MLA：

Mei Zhoufang, et al. "MicroRNA-141 promotes the proliferation of non-small cell lung cancer cells by regulating expression of PHLPP1 and PHLPP2" .FEBS LETTERS 588,17(2014):3055-3061.

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