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NKT cells mediate the recruitment of neutrophils by stimulating epithelial chemokine secretion during colitis 期刊论文

编号：

a7e1e5f6-ba64-4ec4-b642-d3b0dfe62ad7
作者：

Huang, Enyu(黄恩宇)#^[1,2]Liu, Ronghua(刘荣花)^[1,2]Lu, Zhou^[1,2];Liu, Jiajing^[1,2];Liu, Xiaoming^[4];Zhang, Dan(张丹)^[1,2]Chu, Yiwei(储以微)*^[1,2,3]
语种：

English
期刊：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS ISSN：0006-291X 2016 年 474 卷 2 期 (252 - 258) ; MAY 27
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关键词：

Inflammatory bowel disease Natural killer T cell Neutrophil Colitis-associated colorectal cancer
摘要：

Ulcerative colitis (UC) is a kind of inflammatory bowel diseases characterized by chronic inflammation and ulcer in colon, and UC patients have increased risk of getting colorectal cancer. NKT cells are cells that express both NK cell markers and semi-invariant CD1d-restricted TCRs, can regulate immune responses via secreting a variety of cytokines upon activation. In our research, we found that the NKT cell-deficient CD1d(-/-) mice had relieved colitis in the DSS-induced colitis model. Further investigations revealed that the colon of CD1d(-/-) mice expressed less neutrophil-attracting chemokine CXCL 1, 2 and 3, and had decreased neutrophil infiltration. Infiltrated neutrophils also produced less reactive oxygen species (ROS) and TNF-alpha, indicating they may cause less epithelial damage. In addition, colitis-associated colorectal cancer was also relieved in CD1d(-/-) mice. During colitis, NKT cells strongly expressed TNF-alpha, which could stimulate CXCL 1, 2, 3 expressions by the epithelium. In conclusion, NKT cells can regulate colitis via the NKT cell-epithelium-neutrophil axis. Targeting this mechanism may help to improve the therapy of UC and prevent colitis-associated colorectal cancer. (C) 2016 Elsevier Inc. All rights reserved.
推荐引用方式
GB/T 7714：

Huang Enyu,Liu Ronghua,Lu Zhou, et al. NKT cells mediate the recruitment of neutrophils by stimulating epithelial chemokine secretion during colitis [J].BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2016,474(2):252-258.
APA：

Huang Enyu,Liu Ronghua,Lu Zhou,Liu Jiajing,&Chu Yiwei.(2016).NKT cells mediate the recruitment of neutrophils by stimulating epithelial chemokine secretion during colitis .BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,474(2):252-258.
MLA：

Huang Enyu, et al. "NKT cells mediate the recruitment of neutrophils by stimulating epithelial chemokine secretion during colitis" .BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 474,2(2016):252-258.

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