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Genetic variation at 8q24, family history of cancer, and upper gastrointestinal cancers in a Chinese population 期刊论文

编号：

a8ab8dac-e5b3-46c1-ad9a-d08ab57deb25
作者：

Tarleton, Heather P.^[1];Chang, ShenChih^[2];Park, Sungshim Lani^[3];Cai, Lin^[4];Ding, Baoguo^[5];He, Na(何纳)^[6]Hussain, Shehnaz K.^[2,7];Jiang, Qingwu(姜庆五)^[6]Mu, LiNa^[8];Rao, Jianyu^[2];Wang, Hua^[9];You, NaiChieh Y.^[2];Yu, ShunZhang(俞顺章)^[6]Zhao, JinKou^[10];Zhang, ZuoFeng^[2,7];
语种：

English
期刊：

FAMILIAL CANCER ISSN：1389-9600 2014 年 13 卷 1 期 (45 - 56) ; MAR
收录：
关键词：

Liver cancer Stomach cancer Esophageal cancer Hepatitis B 8q24 SNPs Family history of cancer
摘要：

Genetic variation at 8q24 is associated with prostate, bladder, breast, colorectal, thyroid, lung, ovarian, UADT, liver and stomach cancers. However, a role for variation at 8q24 in familial clustering of upper gastrointestinal cancers has not been studied. In order to explore potential inherited susceptibility, we analyzed epidemiologic data from a population-based case-control study of upper gastrointestinal cancers from Taixing, China. The study population includes 204 liver, 206 stomach, and 218 esophageal cancer cases and 415 controls. Associations between 8q24 rs1447295, rs16901979, rs6983267 and these cancers were stratified by family history of cancer. Odds ratios and 95 % confidence intervals were adjusted for potential confounders: age, sex, education, tobacco smoking, alcohol consumption, and BMI at interview. We also adjusted for hepatitis B and aflatoxin (liver cancer) and Helicobacter pylori (stomach cancer). In a dominant model, among those with a family history of cancer, rs1447295 was positively associated with liver cancer (ORadj 2.80; 95 % CI 1.15-6.80). Heterogeneity was observed (P (heterogeneity) = 0.029) with rs6983267 and liver cancer, with positive association in the dominant model among those with a family history of cancer and positive association in the recessive model among those without a family history of cancer. When considered in a genetic risk score model, each additional 8q24 risk genotype increased the odds of liver cancer by two-fold among those with a family history of cancer (ORadj 2.00; 95 % CI 1.15-3.47). These findings suggest that inherited susceptibility to liver cancer may exist in the Taixing population and that variation at 8q24 might be a genetic component of that inherited susceptibility.
推荐引用方式
GB/T 7714：

Tarleton Heather P.,Chang Shen-Chih,Park Sungshim Lani, et al. Genetic variation at 8q24, family history of cancer, and upper gastrointestinal cancers in a Chinese population [J].FAMILIAL CANCER,2014,13(1):45-56.
APA：

Tarleton Heather P.,Chang Shen-Chih,Park Sungshim Lani,Cai Lin,&Zhang Zuo-Feng.(2014).Genetic variation at 8q24, family history of cancer, and upper gastrointestinal cancers in a Chinese population .FAMILIAL CANCER,13(1):45-56.
MLA：

Tarleton Heather P., et al. "Genetic variation at 8q24, family history of cancer, and upper gastrointestinal cancers in a Chinese population" .FAMILIAL CANCER 13,1(2014):45-56.

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