Dynamics of nucleosome positioning affects chromatin state, transcription and all other biological processes occurring on genomic DNA. While MNase-Seq has been used to depict nucleosome positioning map in eukaryote in the past years, nucleosome positioning data is increasing dramatically. To facilitate the usage of published data across studies, we developed a database named nucleosome positioning map (NucMap, http://bigd.big.ac.cn/nucmap). NucMap includes 798 experimental data from 477 samples across 15 species. With a series of functional modules, users can search profile of nucleosome positioning at the promoter region of each gene across all samples and make enrichment analysis on nucleosome positioning data in all genomic regions. Nucleosome browser was built to visualize the profiles of nucleosome positioning. Users can also visualize multiple sources of omics data with the nucleosome browser and make side-by-side comparisons. All processed data in the database are freely available. NucMap is the first comprehensive nucleosome positioning platform and it will serve as an important resource to facilitate the understanding of chromatin regulation.
[1]Mayo Clin, Dept Hlth Sci Res, Jacksonville, FL 32224 USA;
[2]Chinese Acad Sci, BIG Data Ctr, Beijing Inst Genom, Beijing 100101, Peoples R China;
[3]Chinese Acad Sci, CAS Key Lab Genome Sci & Informat, Beijing Inst Genom, Beijing 100101, Peoples R China;
[4]Univ Chinese Acad Sci, Coll Life Sci, Beijing 100049, Peoples R China;
[5]Fudan Univ, Collaborat Innovat Ctr Genet & Dev, Shanghai 200438, Peoples R China
(8.0+极速模式)