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Circular RNA profile identifies circPVT1 as a proliferative factor and prognostic marker in gastric cancer 期刊论文 WOS高被引论文

编号：

aa68e4cf-15ba-493d-8099-2ace2c093763
作者：

Chen, Jie^[1,2,3];Li, Yan(李延)^[1,2,3]Zheng, Qiupeng^[1,2,3,4];Bao, Chunyang^[1,2,3];He, Jian^[1,2,3];Chen, Bin^[1,2,3];Lyu, Dongbin^[1,2,3];Zheng, Biqiang^[1,2,3];Xu, Yu^[1,2,3];Long, Ziwen^[1,2,3];Zhou, Ye^[1,2,3];Zhu, Huiyan^[1,2,3];Wang, Yanong^[1,2,3];He, Xianghuo(何祥火)^[1,2,3]Shi, Yingqiang^[1,2,3];Huang, Shenglin(黄胜林)*^[1,2,3]
语种：

英文
期刊：

CANCER LETTERS ISSN：0304-3835 2017 年 388 卷 (208 - 219) ; MAR 1
收录：
关键词：

Gastric cancer Circular RNA Non-coding RNA circPVT1 Prognosis
摘要：

Circular RNAs (circRNAs) comprise a novel class of widespread non-coding RNAs that may regulate gene expression in eukaryotes. However, the characterization and function of circRNAs in human cancer remain elusive. Here we identified at least 5500 distinct circRNA candidates and a series of circRNAs that are differentially expressed in gastric cancer (GC) tissues compared with matched normal tissues. We further characterized one circRNA derived from the PVT1 gene and termed it as circPVT1. The expression of circPVT1 is often upregulated in GC tissues due to the amplification of its genomic locus. circPVT1 may promote cell proliferation by acting as a sponge for members of the miR-125 family. The level of circPVT1 was observed as an independent prognostic marker for overall survival and disease-free survival of patients with GC. Our findings suggest that circPVT1 is a novel proliferative factor and prognostic marker in GC. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
推荐引用方式
GB/T 7714：

Chen Jie,Li Yan,Zheng Qiupeng, et al. Circular RNA profile identifies circPVT1 as a proliferative factor and prognostic marker in gastric cancer [J].CANCER LETTERS,2017,388:208-219.
APA：

Chen Jie,Li Yan,Zheng Qiupeng,Bao Chunyang,&Huang Shenglin.(2017).Circular RNA profile identifies circPVT1 as a proliferative factor and prognostic marker in gastric cancer .CANCER LETTERS,388:208-219.
MLA：

Chen Jie, et al. "Circular RNA profile identifies circPVT1 as a proliferative factor and prognostic marker in gastric cancer" .CANCER LETTERS 388(2017):208-219.

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