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5,4 '-Dihydroxy-7,8-dimethoxyflavanone and Aliarin from Dodonaea viscosa Are Activators of PPAR gamma 期刊论文

编号：

aa9b6929-fe75-4a3c-add9-257b5c260996
作者：

Zhu, Jingjie^[1,3];Ji, Jun^[2];Hou, AiJun(侯爱君)*^[2]Wang, HeYao^[1];
语种：

English
期刊：

PLANTA MEDICA ISSN：0032-0943 2018 年 84 卷 8 期 (500 - 506) ; MAY
收录：
关键词：

Dodonaea viscosa Sapindaceae 5,4 ' dihydroxy-7,8-dime-thoxyflavanone aliarin diabetes mellitus adipogenesis partial PPAR gamma agonists
摘要：

PPAR gamma agonists are widely used medications in diabetes mellitus therapy. Their role in improving adipose tissue function contributes to antidiabetic effects. The extracts of Dodonaea viscosa have been reported to exert antidiabetic activity. However, the effective mediators and the underlying mechanisms were largely unknown. In this study, we investigated the action on PPAR. transactivation and adipocyte modulation of two typical flavonoid constituents from D. viscosa, 5,4'-dihydroxy- 7,8-dimethoxyflavanone and aliarin. Our results showed that 5,4'-dihydroxy-7,8-dimethoxyflavanone and aliarin were potential partial PPAR. agonists. The compounds induced adipogenesis in 3T3-L1 cells, with an upregulated adiponectin mRNA level and enhanced insulin sensitivity. The favorable effects of 5,4'-dihydroxy-7,8-dimethoxyflavanone, aliarin, and other flavonoid constituents on adipocytes might contribute to the antidiabetic efficacy of D. viscosa.
推荐引用方式
GB/T 7714：

Zhu Jing-jie,Ji Jun,Hou Ai-Jun, et al. 5,4 '-Dihydroxy-7,8-dimethoxyflavanone and Aliarin from Dodonaea viscosa Are Activators of PPAR gamma [J].PLANTA MEDICA,2018,84(8):500-506.
APA：

Zhu Jing-jie,Ji Jun,Hou Ai-Jun,Wang He-Yao.(2018).5,4 '-Dihydroxy-7,8-dimethoxyflavanone and Aliarin from Dodonaea viscosa Are Activators of PPAR gamma .PLANTA MEDICA,84(8):500-506.
MLA：

Zhu Jing-jie, et al. "5,4 '-Dihydroxy-7,8-dimethoxyflavanone and Aliarin from Dodonaea viscosa Are Activators of PPAR gamma" .PLANTA MEDICA 84,8(2018):500-506.

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