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Roles of human papillomavirus infection and stathmin in the pathogenesis of sinonasal inverted papilloma 期刊论文

编号：

ab3e2e0d-277d-43bd-85b3-a9ad3cba7fb4
作者：

Lin, Hai^[1,2] Lin, Dong^[3] Xiong, XiSheng^[4]
语种：

English
期刊：

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK ISSN：1043-3074 2016 年 38 卷 2 期 (220 - 224) ; FEB
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关键词：

human papillomavirus stathmin Kif2a cyclin D1 sinonasal inverted papilloma
摘要：

BackgroundThe purpose of this study was to investigate roles of human papillomavirus (HPV) infection and stathmin in sinonasal inverted papilloma (SNIP). MethodsHPV DNA detection was performed by the fluorescence-based polymerase chain reaction (PCR) method. Stathmin protein expression was investigated by the immunohistochemistry method and mRNA expression of stathmin, Kif2a, and cyclin D1 were assessed by real-time PCR in SNIP and control subjects. ResultsThe positive rate of HPV DNA detected in SNIP was about 53.6% (15 of 28). Recurrent cases showed a higher rate of HPV infection compared with initial cases and higher Krouse stage (T3+T4) cases showed higher rate of HPV infection than lower Krouse stage (T1+T2) cases. Stronger expression of stathmin, Kif2a, and cyclin D1 were observed in SNIP, especially HPV(+) SNIP. ConclusionHPV infection was closely associated with recurrence and progression of SNIP. Stathmin is a valuable prognostic marker and could be considered as a therapeutic target in patients with SNIP. (c) 2015 Wiley Periodicals, Inc. Head Neck 38: 220-224, 2016
推荐引用方式
GB/T 7714：

Lin Hai,Lin Dong,Xiong Xi-Sheng, et al. Roles of human papillomavirus infection and stathmin in the pathogenesis of sinonasal inverted papilloma [J].HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK,2016,38(2):220-224.
APA：

Lin Hai,Lin Dong,Xiong Xi-Sheng.(2016).Roles of human papillomavirus infection and stathmin in the pathogenesis of sinonasal inverted papilloma .HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK,38(2):220-224.
MLA：

Lin Hai, et al. "Roles of human papillomavirus infection and stathmin in the pathogenesis of sinonasal inverted papilloma" .HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK 38,2(2016):220-224.

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