首页 / 院系成果 / 成果详情页

Blockade of CRF1 and CCK2 receptors attenuated the elevated anxiety-like behavior induced by immobilization stress 期刊论文

编号：

abf0928e-2033-4130-ab36-eb3615748a3b
作者：

Wang, Hong^[1];Spiess, Jachim^[2];Wong, Peter T. H.^[1];Zhu, Yi Zhun(朱依谆)^[1,3]
语种：

English
期刊：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR ISSN：0091-3057 2011 年 98 卷 3 期 (362 - 368) ; MAY
收录：
关键词：

Elevated plus maze Immobilization stress Real-time RT-PCR Western blot Antagonist CR2945 Antalarmin Corticotropin-releasing factor Cholecystokinin
摘要：

Two highly co-localized neurotransmitters: corticotropin-releasing factor (CRF) and cholecystokinin (CCK), have been implicated in the development of stress-related anxiety disorders. This study was designed to examine the role of CRF1 and CCK2 receptors on the anxiety-like behavior induced by immobilization stress. Our results showed that 30-min immobilization enhanced the anxiety-like behavior in C57BL/6J mice examined in the elevated plus maze (EPM). The combined pretreatment of CR2945 (a CCK2 receptor antagonist) and antalarmin (a CRF1 receptor antagonist) fully blocked this elevated anxiety-like behavior, while the application of CR2945 or antalarmin alone showed only partial effects. The increased expression of CRF1 and CCK2 receptors at protein levels in three anxiety-related brain regions: cortex, hippocampus and hypothalamus, was detected by Western blot. The increased mRNA expression of CCK, CRF, CCK2 and CRF1 receptors was also examined by real-time RT-PCR. Our study demonstrated that the blockade of CRF1 and CCK2 receptors attenuated the elevated anxiety-like behavior induced by immobilization stress, suggestive of the CRF and CCK systems contributing to the development of stress-related anxiety behavior. (C) 2011 Elsevier Inc. All rights reserved.
推荐引用方式
GB/T 7714：

Wang Hong,Spiess Jachim,Wong Peter T. -H., et al. Blockade of CRF1 and CCK2 receptors attenuated the elevated anxiety-like behavior induced by immobilization stress [J].PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,2011,98(3):362-368.
APA：

Wang Hong,Spiess Jachim,Wong Peter T. -H.,Zhu Yi Zhun.(2011).Blockade of CRF1 and CCK2 receptors attenuated the elevated anxiety-like behavior induced by immobilization stress .PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,98(3):362-368.
MLA：

Wang Hong, et al. "Blockade of CRF1 and CCK2 receptors attenuated the elevated anxiety-like behavior induced by immobilization stress" .PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 98,3(2011):362-368.

浏览次数：2  下载次数：0

分享到：

浏览次数：2

下载次数：0

打印次数：0