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Elevated FUS/TLS expression is negatively associated with E-cadherin expression and prognosis of patients with non-small cell lung cancer 期刊论文

编号：

adbf1981-ba4c-4375-bc17-b9878de2ca78
作者：

Xiong, Dian^[1,2];Wu, YongBing^[1];Jin, Chun^[2];Li, JiJun^[2,3];Gu, Jie(古杰)^[2]Liao, YunFei^[1];Long, Xiang^[1];Zhu, ShuQiang^[1];Wu, HaiBo^[1];Xu, JianJun^[1];Ding, JianYong(丁建勇)*^[2]
语种：

English
期刊：

ONCOLOGY LETTERS ISSN：1792-1074 2018 年 16 卷 2 期 (1791 - 1800) ; AUG
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关键词：

fused in sarcoma translocated in liposarcoma non-small cell lung cancer E-cadherin prognosis survival
摘要：

Fused in sarcoma/translocated in liposarcoma (FUS/TLS), a ubiquitous and multifunctional DNA and RNA-binding protein, contributes an important function in cancer and neurodegenerative disease; however, its role in lung cancer remains unclear. In the present study, the expression of FUS/TLS in non-small cell lung cancer (NSCLC) and the significance of FUS/TLS for predicting the clinical outcome of patients with NSCLC, was examined. FUS/TLS expression was investigated in NSCLC tissues and their matched adjacent non-tumorous tissues by reverse transcription-quantitative polymerase chain reaction, western blotting, and immunohistochemistry. Tissue microarrays representing 208 patients with NSCLC were used to determine the expression pattern and associations with FUS/TLS using immunohistochemistry. Prognostic significance was assessed by Kaplan-Meier survival estimates and log-rank tests. Data revealed that FUS/TLS expression was elevated in NSCLC tissues compared with corresponding normal tissue mRNA (9.27 +/- 0.73 vs. 6.15 +/- 0.60) and protein (3.32 +/- 0.75 vs. 0.30 +/- 0.07) levels. In tissue microarrays, FUS/TLS was highly expressed in 103 (49.5%, 103/208) NSCLC tissues compared with adjacent normal lung tissues (28.4%, 59/208). Overexpression of FUS/TLS was associated with higher tumor node metastasis stage (P=0.016), poorer differentiation (P=0.008), large tumor size (P=0.019) and predicted poor prognosis (P=0.005) in patients with NSCLC. Notably, correlation analysis revealed a significant inverse association between the expression of FUS/TLS and E-cadherin (r(2)=0.51; P=0.036). Furthermore, patients with NSCLC with high FUS/TLS and impaired E-cadherin expression had a notably poor prognosis (P=4.01x10(-4)). Thus, the results from the present study indicate that elevated FUS/TLS expression promotes NSCLC progression. FUS/TLS, alone or in combination with E-cadherin, is a novel prognostic predictor for patients with NSCLC.
推荐引用方式
GB/T 7714：

Xiong Dian,Wu Yong-Bing,Jin Chun, et al. Elevated FUS/TLS expression is negatively associated with E-cadherin expression and prognosis of patients with non-small cell lung cancer [J].ONCOLOGY LETTERS,2018,16(2):1791-1800.
APA：

Xiong Dian,Wu Yong-Bing,Jin Chun,Li Ji-Jun,&Ding Jian-Yong.(2018).Elevated FUS/TLS expression is negatively associated with E-cadherin expression and prognosis of patients with non-small cell lung cancer .ONCOLOGY LETTERS,16(2):1791-1800.
MLA：

Xiong Dian, et al. "Elevated FUS/TLS expression is negatively associated with E-cadherin expression and prognosis of patients with non-small cell lung cancer" .ONCOLOGY LETTERS 16,2(2018):1791-1800.

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