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Sham-controlled, randomised, feasibility trial of acupuncture for prevention of radiation-induced xerostomia among patients with nasopharyngeal carcinoma 期刊论文

编号：

b0303695-680f-4b04-aa43-7a0b3cfc7a79
作者：

Meng, Zhiqiang^[2];Garcia, M. Kay^[1];Hu, Chaosu^[3];Chiang, Joseph^[4];Chambers, Mark^[5];Rosenthal, David I.^[6];Peng, Huiting^[2];Wu, Caijun^[2];Zhao, Qi(赵琦)^[7]Zhao, Genming^[7];Liu, Luming^[2];Spelman, Amy^[1,8];Palmer, J. Lynn^[9];Wei, Qi^[1,8];Cohen, Lorenzo^[1,8];
语种：

English
期刊：

EUROPEAN JOURNAL OF CANCER ISSN：0959-8049 2012 年 48 卷 11 期 (1692 - 1699) ; JUL
收录：
关键词：

Acupuncture Xerostomia Head and neck cancer Quality of life Complementary medicine
摘要：

Background: Xerostomia (dry mouth) after head/neck radiation is a common problem among cancer patients. Quality of life (QOL) is impaired, and available treatments are of little benefit. This trial determined the feasibility of conducting a sham-controlled trial of acupuncture and whether acupuncture could prevent xerostomia among head/neck patients undergoing radiotherapy. Methods: A sham controlled, feasibility trial was conducted at Fudan University Shanghai Cancer Center, Shanghai, China among patients with nasopharyngeal carcinoma undergoing radiotherapy. To determine feasibility of a sham procedure, 23 patients were randomised to real acupuncture (N = 11) or to sham acupuncture (N = 12). Patients were treated three times/week during the course of radiotherapy. Subjective measures were the Xerostomia Questionnaire (XQ) and MD Anderson Symptom Inventory for Head and Neck Cancer (MDASI-HN). Objective measures were unstimulated whole salivary flow rates (UWSFR) and stimulated salivary flow rates (SSFR). Patients were followed for 1 month after radiotherapy. Results: XQ scores for acupuncture were significantly lower than sham controls starting in week 3 and lasted through the 1-month follow-up (all P's <0.001 except for week 3, which was 0.006), with clinically significant differences as follows: week 6 - RR 0.28 [95% confidence interval, 0.10, 0.79]; week 11 - RR 0.17 [95% CI, 0.03, 1.07]. Similar findings were seen for MDASI-HN scores and MDASI-Intrusion scores. Group differences for UWSFR and SSFR were not found. Conclusions: In this small pilot study, true acupuncture given concurrently with radiotherapy significantly reduced xerostomia symptoms and improved QOL when compared with sham acupuncture. Large-scale, multi-centre, randomised and placebo-controlled trials are now needed. (C) 2012 Elsevier Ltd. All rights reserved.
推荐引用方式
GB/T 7714：

Meng Zhiqiang,Garcia M. Kay,Hu Chaosu, et al. Sham-controlled, randomised, feasibility trial of acupuncture for prevention of radiation-induced xerostomia among patients with nasopharyngeal carcinoma [J].EUROPEAN JOURNAL OF CANCER,2012,48(11):1692-1699.
APA：

Meng Zhiqiang,Garcia M. Kay,Hu Chaosu,Chiang Joseph,&Cohen Lorenzo.(2012).Sham-controlled, randomised, feasibility trial of acupuncture for prevention of radiation-induced xerostomia among patients with nasopharyngeal carcinoma .EUROPEAN JOURNAL OF CANCER,48(11):1692-1699.
MLA：

Meng Zhiqiang, et al. "Sham-controlled, randomised, feasibility trial of acupuncture for prevention of radiation-induced xerostomia among patients with nasopharyngeal carcinoma" .EUROPEAN JOURNAL OF CANCER 48,11(2012):1692-1699.

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