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The kinase CK1 epsilon controls the antiviral immune response by phosphorylating the signaling adaptor TRAF3 期刊论文

编号：

b03b1d55-4dc6-4796-9be9-4665dd0113cd
作者：

Zhou, Yilong^[1];He, Chenxi^[1];Yan, Dapeng^[2,3];Liu, Feng^[2,3];Liu, Haipeng^[1];Chen, Jianxia^[1];Cao, Ting^[1];Zuo, Mianyong^[1];Wang, Peng^[1];Ge, Yan^[1];Lu, Haojie(陆豪杰)^[4,5]Tong, Qinghe^[4,5];Qin, Chengfeng^[6];Deng, Yongqiang^[6];Ge, Baoxue^[1];
语种：

English
期刊：

NATURE IMMUNOLOGY ISSN：1529-2908 2016 年 17 卷 4 期 (397 - +) ; APR
收录：
摘要：

The signaling adaptor TRAF3 is a highly versatile regulator of both innate immunity and adaptive immunity, but how its phosphorylation is regulated is still unknown. Here we report that deficiency in or inhibition of the conserved serine-threonine kinase CK1 epsilon suppressed the production of type I interferon in response to viral infection. CK1 epsilon interacted with and phosphorylated TRAF3 at Ser349, which thereby promoted the Lys63 (K63)-linked ubiquitination of TRAF3 and subsequent recruitment of the kinase TBK1 to TRAF3. Consequently, CK1 epsilon-deficient mice were more susceptible to viral infection. Our findings establish CK1 epsilon as a regulator of antiviral innate immune responses and indicate a novel mechanism of immunoregulation that involves CK1 epsilon-mediated phosphorylation of TRAF3.
推荐引用方式
GB/T 7714：

Zhou Yilong,He Chenxi,Yan Dapeng, et al. The kinase CK1 epsilon controls the antiviral immune response by phosphorylating the signaling adaptor TRAF3 [J].NATURE IMMUNOLOGY,2016,17(4):397-+.
APA：

Zhou Yilong,He Chenxi,Yan Dapeng,Liu Feng,&Ge Baoxue.(2016).The kinase CK1 epsilon controls the antiviral immune response by phosphorylating the signaling adaptor TRAF3 .NATURE IMMUNOLOGY,17(4):397-+.
MLA：

Zhou Yilong, et al. "The kinase CK1 epsilon controls the antiviral immune response by phosphorylating the signaling adaptor TRAF3" .NATURE IMMUNOLOGY 17,4(2016):397-+.

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