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Effects of Genetic and Nongenetic Factors on Total and Bioavailable 25(OH)D Responses to Vitamin D Supplementation 期刊论文

编号：

b32b0e13-728a-41b3-a665-5c18555fa121
作者：

Yao, Pang^[1] Sun, Liang^[1] Lu, Ling^[1] Ding, Hong^[4] Chen, Xiafei^[5] Tang, Lixin^[5] Xu, Xinming^[6] Liu, Gang^[1] Hu, Yao^[1] Ma, Yiwei^[1] Wang, Feijie^[1] Jin, Qianlu^[1] Zheng, He^[1] Yin, Huiyong^[1] Zeng, Rong^[2,3] Chen, Yan^[1] Hu, Frank B.^[7,8] Li, Huaixing^[1] Lin, Xu^[1]
语种：

English
期刊：

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM ISSN：0021-972X 2017 年 102 卷 1 期 (100 - 110) ; JAN
收录：
摘要：

Context: Little is known about how genetic and nongenetic factors modify responses of vitamin D supplementation in nonwhite populations. Objective: To investigate factorsmodifying 25-hydroxyvitaminD[25(OH) D] and bioavailable 25(OH)D [25(OH)D-Bio] responses after vitamin D3 supplementation. Design, Setting, Participants, and Intervention: In this 20-week, randomized, double-blinded, placebo-controlled trial, 448 Chinese with vitamin D deficiency received 2000 IU/d vitamin D-3 or placebo. Main Outcome Measures: Serum 25(OH) D, vitamin D-binding protein (VDBP), parathyroid hormone (PTH) and calcium were measured, and 25(OH)D-Bio was calculated based on VDBP levels. Six common polymorphisms in vitamin D metabolism genes were genotyped. Results: Between-armnet changeswere + 30.6 +/- 1.7 nmol/L for 25(OH)D, + 2.7 +/- 0.2 nmol/L for 25(OH) D-Bio, and -5.2 +/- 1.2 pg/mL for PTH, corresponding to 70% [95% confidence interval (CI), 62.8% to 77.2%] net reversion rate for vitamin D deficiency atweek 20 (P < 0.001). Only 25(OH) DBio changewas positively associated with calcium change (P < 0.001). Genetic factors (GC-rs4588/GC-rs7041, VDR-rs2228570, and CYP2R1-rs10741657; P # 0.04) showed stronger influences on 25(OH)D or 25(OH)D-Bio responses than nongenetic factors, including baseline value, body mass index, and sex. An inverse association of PTH-25(OH) Dwas demonstrated only at 25(OH)D of, 50.8 (95% CI, 43.6 to 59.0) nmol/L. Conclusions: Supplemented 2000 IU/d vitamin D3 raised 25(OH)D and 25(OH)D-Bio but was unable to correct deficiency in 25% of Chinese participants, which might be partially attributed to the effect of geneticmodification. More studies are needed to elucidate appropriate vitaminDrecommendations for Asians and the potential clinical implications of 25(OH)D-Bio.
推荐引用方式
GB/T 7714：

Yao Pang,Sun Liang,Lu Ling, et al. Effects of Genetic and Nongenetic Factors on Total and Bioavailable 25(OH)D Responses to Vitamin D Supplementation [J].JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM,2017,102(1):100-110.
APA：

Yao Pang,Sun Liang,Lu Ling,Ding Hong,&Lin Xu.(2017).Effects of Genetic and Nongenetic Factors on Total and Bioavailable 25(OH)D Responses to Vitamin D Supplementation .JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM,102(1):100-110.
MLA：

Yao Pang, et al. "Effects of Genetic and Nongenetic Factors on Total and Bioavailable 25(OH)D Responses to Vitamin D Supplementation" .JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 102,1(2017):100-110.

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