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Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci  期刊论文   WOS高被引论文

  • 编号：
    b3d26c25-2ebe-4077-86b8-d54cd3c9660b
  • 作者：
    Schumacher, Fredrick R.[1,2,143];Al Olama, Ali Amin[3,4,143];Berndt, Sonja I.[5,143];Benlloch, Sara[3,6];Ahmed, Mahbubl[6];Saunders, Edward J.[6];Dadaev, Tokhir[6];Leongamornlert, Daniel[6];Anokian, Ezequiel[6];CiezaBorrella, Clara[6];Goh, Chee[6];Brook, Mark N.[6];Sheng, Xin[7];Fachal, Laura[8,9];Dennis, Joe[3];Tyrer, Jonathan[3];Muir, Kenneth[10,11];Lophatananon, Artitaya[10,11];Stevens, Victoria L.[12];Gapstur, Susan M.[12];Carter, Brian D.[12];Tangen, Catherine M.[13];Goodman, Phyllis J.[13];Thompson, Ian M., Jr.[14];Batra, Jyotsna[15,16,17];Chambers, Suzanne[18,19];Moya, Leire[15,16,17];Clements, Judith[15,16,17];Horvath, Lisa[20,21];Tilley, Wayne[22];Risbridger, Gail P.[23,24];Gronberg, Henrik[25];Aly, Markus[26,27];Nordstrom, Tobias[25,28];Pharoah, Paul[3,9];Pashayan, Nora[9,29];Schleutker, Johanna[30,31];Tammela, Teuvo L. J.[32,33];Sipeky, Csilla[30];Auvinen, Anssi[34];Albanes, Demetrius[5];Weinstein, Stephanie[5];Wolk, Alicja[35,36];Hakansson, Niclas[35];West, Catharine M. L.[37,38];Dunning, Alison M.[9];Burnet, Neil[39];Mucci, Lorelei A.[40];Giovannucci, Edward[40];Andriole, Gerald L.[41];Cussenot, Olivier[42,43];CancelTassin, Geraldine[42,43];Koutros, Stella[5];Freeman, Laura E. Beane[5];Sorensen, Karina Dalsgaard[44,45];Orntoft, Torben Falck[44,45];Borre, Michael[45,46];Maehle, Lovise[47];Grindedal, Eli Marie[47];Neal, David E.[48,49,50,51];Donovan, Jenny L.[52];Hamdy, Freddie C.[50,51];Martin, Richard M.[52];Travis, Ruth C.[53];Key, Tim J.[53];Hamilton, Robert J.[54];Fleshner, Neil E.[54];Finelli, Antonio[5,55];Ingles, Sue Ann[7];Stern, Mariana C.[7];Rosenstein, Barry S.[5,56,57];Kerns, Sarah L.[58];Ostrer, Harry[5,59];Lu, YongJie[60];Zhang, HongWei[5,61];Feng, Ninghan[62];Mao, Xueying[60];Guo, Xin[63];Wang, Guomin(王国民)[64]Sun, Zan[65];Giles, Graham G.[66,67];Southey, Melissa C.[68];MacInnis, Robert J.[66,67];FitzGerald, Liesel M.[66,69];Kibel, Adam S.[70];Drake, Bettina F.[41];Vega, Ana[71];GomezCaamano, Antonio[72];Szulkin, Robert[73,74];Eklund, Martin[25];Kogevinas, Manolis[75,76,77,78];Llorca, Javier[76,79];CastanoVinyals, Gemma[75,76,77,78];Penney, Kathryn L.[80,81];Stampfer, Meir[80,81];Park, Jong Y.[82];Sellers, Thomas A.[82];Lin, HuiYi[83];Stanford, Janet L.[84,85];Cybulski, Cezary[86];Wokolorczyk, Dominika[86];Lubinski, Jan[86];Ostrander, Elaine A.[87];Geybels, Milan S.[84];Nordestgaard, Borge G.[88,89];Nielsen, Sune F.[88,89];Weischer, Maren[89];Bisbjerg, Rasmus[90];Roder, Martin Andreas[91];Iversen, Peter[91];Brenner, Hermann[92,93,94,95];Cuk, Katarina[92];Holleczek, Bernd[96];Maier, Christiane[97];Luedeke, Manuel[97];Schnoeller, Thomas[98];Kim, Jeri[99];Logothetis, Christopher J.[99];John, Esther M.[100,101,102];Teixeira, Manuel R.[103,104];Paulo, Paula[103];Cardoso, Marta[103];Neuhausen, Susan L.[105];Steele, Linda[105];Ding, Yuan Chun[105];De Ruyck, Kim[106];De Meerleer, Gert[106];Ost, Piet[107];Razack, Azad[108];Lim, Jasmine[108];Teo, SooHwang[109];Lin, Daniel W.[84,110];Newcomb, Lisa F.[84,110];Lessel, Davor[111];Gamulin, Marija[5,112];Kulis, Tomislav[113];Kaneva, Radka[114];Usmani, Nawaid[115,116];Singhal, Sandeep[115,116];Slavov, Chavdar[117,118];Mitev, Vanio[114];Parliament, Matthew[115,116];Claessens, Frank[119];Joniau, Steven[120];Van den Broeck, Thomas[119,120];Larkin, Samantha[121];Townsend, Paul A.[122];AukimHastie, Claire[123];Dominguez, Manuela Gago[124,125];Castelao, Jose Esteban[126];Martinez, Maria Elena[127];Roobol, Monique J.[128];Jenster, Guido[128];van Schaik, Ron H. N.[129];Menegaux, Florence[130];Truong, Therese[130];Koudou, Yves Akoli[130];Xu, Jianfeng[131];Khaw, KayTee[132];CannonAlbright, Lisa[133,134];Pandha, Hardev[123];Michael, Agnieszka[123];Thibodeau, Stephen N.[135];McDonnell, Shannon K.[136];Schaid, Daniel J.[135];Lindstrom, Sara[85];Turman, Constance[137];Ma, Jing[80,81];Hunter, David J.[137];Riboli, Elio[138];Siddiq, Afshan[139];Canzian, Federico[140];Kolonel, Laurence N.[141];Le Marchand, Loic[141];Hoover, Robert N.[5];Machiela, Mitchell J.[5];Cui, Zuxi[1];Kraft, Peter[137];Conti, David V.[7];Easton, Douglas F.[3,9];Wiklund, Fredrik[25];Chanock, Stephen J.[5];Henderson, Brian E.[7];KoteJarai, Zsofia[6];Haiman, Christopher A.[7];Eeles, Rosalind A.[6,143];
  • 语种：
    英文
  • 期刊：
    NATURE GENETICS ISSN：1061-4036 2018 年 50 卷 7 期 (928 - +) ; JUL
  • 收录：
     
  • 摘要：

    Genome-wide association studies (GWAS) and fine-mapping efforts to date have identified more than 100 prostate cancer (PrCa)-susceptibility loci. We meta-analyzed genotype data from a custom high-density array of 46,939 PrCa cases and 27,910 controls of European ancestry with previously genotyped data of 32,255 PrCa cases and 33,202 controls of European ancestry. Our analysis identified 62 novel loci associated (P < 5.0 x 10(-8)) with PrCa and one locus significantly associated with early-onset PrCa (<= 55 years). Our findings include missense variants rs1800057 (odds ratio (OR) = 1.16; P = 8.2 x 10(-9); G>C, p.Pro1054Arg) in ATM and rs2066827 (OR = 1.06; P = 2.3 x 10(-9); T>G, p.Val109Gly) in CDKN1B. The combination of all loci captured 28.4% of the PrCa familial relative risk, and a polygenic risk score conferred an elevated PrCa risk for men in the ninetieth to ninety-ninth percentiles (relative risk = 2.69; 95% confidence interval (CI): 2.55-2.82) and first percentile (relative risk = 5.71; 95% CI: 5.04-6.48) risk stratum compared with the population average. These findings improve risk prediction, enhance fine-mapping, and provide insight into the underlying biology of PrCa1.

  • 推荐引用方式
    GB/T 7714：
    Schumacher Fredrick R.,Al Olama Ali Amin,Berndt Sonja I., et al. Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci [J].NATURE GENETICS,2018,50(7):928-+.
  • APA：
    Schumacher Fredrick R.,Al Olama Ali Amin,Berndt Sonja I.,Benlloch Sara,&Eeles Rosalind A..(2018).Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci .NATURE GENETICS,50(7):928-+.
  • MLA：
    Schumacher Fredrick R., et al. "Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci" .NATURE GENETICS 50,7(2018):928-+.
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