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Evaluation in vinyl chloride monomer (VCM)-exposed workers and the relationship between liver lesions and gene polymorphisms of metabolic enzymes 期刊论文

编号：

b3d53e22-811b-469f-be9c-2626067d1026
作者：

Zhu, ShouMin(朱守民)#Ren, XueFeng;Wan, JunXiang;Xia, ZhaoLin(夏昭林)*^[1]
语种：

English
期刊：

WORLD JOURNAL OF GASTROENTEROLOGY ISSN：1007-9327 2005 年 11 卷 37 期 ; OCT 7
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关键词：

Vinyl chloride monomer Hepatic lesions Cytochrome p450 2E1 Glutathione S-transferase Aldehyde dehydrogenase-2
摘要：

Aim: The permissible exposure limit (PEL) of vinyl chloride monomer (VCM) in developed country was 1 p/m (2.79 mg/m3); and threshold limit value-short term exposure limit (TLV-STEL) in China was 11 times higher [11 p/m (30 mg/m3)] than it, till 2002. The mechanism of vinyl chloride monomer (VCM)-related carcinogenesis remains unclear. We aimed to analyze occupational health hazards exposure to doses lower than the Chinese occupational health standard in a selected VC polymerization plant in China, and also to elucidate the relationship between genetic polymorphisms and genetic susceptibility on liver lesions of workers exposed to VCM. Methods: In order to explore the mechanism of VCM-related health effects, we used a case-control design to investigate the association between the genetic polymorphisms of metabolic enzymes and liver lesions in workers occupationally exposed to VCM. Genotypes of CYP2E1, GSTT1, GSTM1, ALDH2 and ADH2 were identified using PCR and PCR-RFLP. Results: Even when the concentration of VCM was lower than the current Chinese occupational health standard, neurasthenia, pharyngeal irritation, liver ultrasonography abnormalities and hemoglobin disorders were significantly higher in exposure subjects compared to non-exposure subjects, and the relative risks (RR and 95% CI) were 1.74 (1.06-2.85), 1.97 (1.56-2.48), 10.69 (4.38-26.12), and 2.07 (1.20-3.57). CYP2E1 c1c2/c2c2 genotype was significantly associated with liver damages (OR 3.29, 95% CI 1.51-7.20, P<0.01). Conclusion: The incidences of neurasthenia and liver ultrasonography abnormalities significantly increase when the cumulative exposure dose increases. The genotypes of metabolic enzymes (CYP2E1 c1c2/c2c2, null GSTT1 and ADH2 1-1) play important roles in VCM metabolism. Polymorphisms of CYP 2E1, GSTT1 and ADH2 may be a major reason of genetic susceptibility in VCM-induced hepatic damage. (C) 2005 The WJG Press and Elsevier Inc. All rights reserved.
推荐引用方式
GB/T 7714：

Zhu Shou-Min,Ren Xue-Feng,Wan Jun-Xiang, et al. Evaluation in vinyl chloride monomer (VCM)-exposed workers and the relationship between liver lesions and gene polymorphisms of metabolic enzymes [J].WORLD JOURNAL OF GASTROENTEROLOGY,2005,11(37).
APA：

Zhu Shou-Min,Ren Xue-Feng,Wan Jun-Xiang,Xia Zhao-Lin.(2005).Evaluation in vinyl chloride monomer (VCM)-exposed workers and the relationship between liver lesions and gene polymorphisms of metabolic enzymes .WORLD JOURNAL OF GASTROENTEROLOGY,11(37).
MLA：

Zhu Shou-Min, et al. "Evaluation in vinyl chloride monomer (VCM)-exposed workers and the relationship between liver lesions and gene polymorphisms of metabolic enzymes" .WORLD JOURNAL OF GASTROENTEROLOGY 11,37(2005).

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