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Association of Single Nucleotide Polymorphisms in the CYP19A1 Gene with Female Pattern Hair Loss in a Chinese Population  期刊论文  

  • 编号:
    b4d90b4f-8ca3-48d2-95f1-7f1555ece1a5
  • 作者:
  • 语种:
    English
  • 期刊:
    DERMATOLOGY ISSN:1018-8665 2015 年 231 卷 3 期 (239 - 244)
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  • 摘要:

    Background: It has been suggested that the single nucleotide polymorphism (SNP) of the CYP19A1 gene encoding aromatase may affect the development of female pattern hair loss (FPHL). Objective: Our aim was to investigate the association of CYP19A1 gene SNPs with FPHL in a Chinese population. Methods: Two hundred Chinese Han patients with FPHL and 200 controls were enrolled into our study. SNaPshot technology was used to detect CYP19A1 gene candidate SNPs. Results:The allele frequencies and distributions of rs6493497 and rs7176005 were significantly different between FPHL and control subjects (p < 0.001 and p < 0.001 vs. p < 0.001 and p = 0.003). Condusion:The rs6493497 and rs7176005 SNPs of the CYP19A1 gene may be genetic markers that influence the risk of FPHL in this Chinese population. (C) 2015 The Author(s) Published by S. Karger AG, Basel

  • 推荐引用方式
    GB/T 7714:
    Rui Wenlong,Sheng Youyu,Hu Ruiming, et al. Association of Single Nucleotide Polymorphisms in the CYP19A1 Gene with Female Pattern Hair Loss in a Chinese Population [J].DERMATOLOGY,2015,231(3):239-244.
  • APA:
    Rui Wenlong,Sheng Youyu,Hu Ruiming,Miao Ying,&Yang Qinping.(2015).Association of Single Nucleotide Polymorphisms in the CYP19A1 Gene with Female Pattern Hair Loss in a Chinese Population .DERMATOLOGY,231(3):239-244.
  • MLA:
    Rui Wenlong, et al. "Association of Single Nucleotide Polymorphisms in the CYP19A1 Gene with Female Pattern Hair Loss in a Chinese Population" .DERMATOLOGY 231,3(2015):239-244.
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