ObjectivePerfluoroalkyl and polyfluoroalkyl substances (PFASs) are persistent pollutants and have endocrine disruptive and neurotoxic effects. The association between maternal PFAS concentrations and neuropsychological development in children is inconclusive. The present study aimed to examine the effect of maternal PFAS concentrations on neuropsychological development in 4-years-old children.MethodsWe used data from Shanghai-Minhang Birth Cohort, which recruited pregnant women at 12-16 gestational weeks. Among 981 women having PFAS measurement, 533 mother-child pairs were included in the study. A total of eight PFASs were measured, including perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorohexane sulfonate (PFHxS), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), perfluoroundecanoic acid (PFUdA), perfluorododecanoic acid (PFDoA), and perfluorotridecanoic acid (PFTrDA). When infants turned 4years old, mothers were asked to complete the Ages and Stages Questionnaires (R) (ASQ) to assess neuropsychological development of their children. Poisson regression model with robust variance estimates was used to examine the association between maternal PFAS concentrations and each developmental subscale of the ASQ.ResultsPrenatal plasma concentrations of most PFASs tended to be associated with increased risk of development problem in personal-social skills, including PFHxS, PFOS, PFOA, PFNA, PFDA, and PDUdA, and the associations for PFNA and PFDA were significant (per natural log unit increase: RRPFNA=1.92, 95% CI: 1.21, 3.05; RR (PFDA)=1.66, 95% CI: 1.17, 2.37). In stratified analyses by child' sex, the consistent pattern of higher risk of developmental problems in personal-social skills associated with most PFASs was mainly observed among girls (RRPFOS=2.56, 95% CI: 1.20, 5.45; RRPFOA=9.00, 95% CI: 3.82, 21.21; RRPFNA=3.11, 95% CI: 1.36, 7.13; RRPFDA=2.20, 95% CI: 1.21, 4.00; RRPFUdA=2.44, 95% CI: 1.14, 5.20; RRPFDoA=1.62, 95% CI: 1.04, 2.54). Boys with higher maternal PFOA concentrations had a decreased risk of developmental problems in gross motor skills (RR=0.47, 95% CI: 0.25, 0.89).ConclusionPrenatal plasma PFAS concentrations were associated with neuropsychological development in girls at 4years of age, mainly in the subset of personal-social skills.
[1]First Peoples Hosp Jianshan, Jiaxing, Zhejiang, Peoples R China;
[2]Fudan Univ, NHC Key Lab Reprod Regulat, Shanghai Inst Planned Parenthood Res, Shanghai, Peoples R China;
[3]Univ Florida, Dept Pharmaceut Outcomes & Policy, Coll Pharm, 1225 Ctr Dr,HPNP 3338, Gainesville, FL 32610 USA;
[4]Univ Florida, Coll Publ Hlth & Hlth Profess, Dept Epidemiol, 2004 Mowry Rd, Gainesville, FL 32610 USA;
[5]Univ Florida, Coll Med, 2004 Mowry Rd, Gainesville, FL 32610 USA;
[6]Hubei Prov Acad Prevent Med, Natl Reference Lab Dioxin, Inst Hlth Inspect & Detect, Hubei Prov Ctr Dis Control & Prevent, Wuhan 430079, Hubei, Peoples R China;
[7]Weifang Med Univ, Dept Publ Educa, 7166 Baotong West Rd, Weifang 261053, Shandong, Peoples R China;
[8]Weifang Med Univ, Dept Hlth Stat, Sch Publ Hlth & Management, 7166 Baotong West Rd, Weifang 261053, Shandong, Peoples R China
(8.0+极速模式)