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Synthesis and Cytotoxic Activities of the Amino Acid-Conjugates of 10-Hydroxycamptothecin 期刊论文

编号：

b5932e27-4ac3-4baf-b048-b695ae55d876
作者：

Meng Guangrong^[1];Li Jiajun^[1];Wang Guolin^[2];Dong Mengjie^[2];Zhang Qian(张倩)*^[1]
语种：

Chinese
期刊：

CHINESE JOURNAL OF ORGANIC CHEMISTRY ISSN：0253-2786 2014 年 34 卷 1 期 (155 - 160) ; JAN
收录：
关键词：

camptothecin amino acid-conjugates cytotoxic activities
摘要：

A series of amino acid-conjugates of 10-hydroxycamptothecin and 9-nitro-10-hydroxycamptothecin were synthesized by means of a two-carbon side chain from 10-hydroxycamptothecin. The cytotoxic activities of all the synthetic compounds on KB, HepG2 and C26 in vitro were evaluated by CCK-8 assay. The results revealed that part of the conjugates exhibit potent anti-proliferative activities against selected tumor cell lines. Among them, the amino acid-conjugates of 10-hydroxycamptothecin show more potent activities than those of 9-nitro-10-hydroxycamptothecin in vitro as antitumor agents.
推荐引用方式
GB/T 7714：

Meng Guangrong,Li Jiajun,Wang Guolin, 等. Synthesis and Cytotoxic Activities of the Amino Acid-Conjugates of 10-Hydroxycamptothecin [J].CHINESE JOURNAL OF ORGANIC CHEMISTRY,2014,34(1):155-160.
APA：

Meng Guangrong,Li Jiajun,Wang Guolin,Dong Mengjie,&Zhang Qian.(2014).Synthesis and Cytotoxic Activities of the Amino Acid-Conjugates of 10-Hydroxycamptothecin .CHINESE JOURNAL OF ORGANIC CHEMISTRY,34(1):155-160.
MLA：

Meng Guangrong, et al. "Synthesis and Cytotoxic Activities of the Amino Acid-Conjugates of 10-Hydroxycamptothecin" .CHINESE JOURNAL OF ORGANIC CHEMISTRY 34,1(2014):155-160.

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