Human infants with congenital Zika virus (ZIKV) infection exhibit a range of symptoms including microcephaly, intracranial calcifications, macular atrophy and arthrogryposis. More importantly, prognosis data have lagged far behind the recent outbreak of ZIKV in 2015. In this work, we allow congenitally ZIKV-infected mice to grow into puberty. These mice exhibited motor incoordination and visual dysfunctions, which can be accounted by anatomical defects in the retina and cerebellar cortex. In contrary, anxiety level of the ZIKV-infected mice is normal. The spectrum of anatomical and behavioral deficits is consistent across different mice. Our data provided evidence that may help predict the public health burden in terms of prognosis of ZIKV-related congenital brain malformations in an animal model. Our study provided behavioral evaluation for the prognosis of congenital ZIKV infection and provides a platform for screening and evaluation of drugs candidates and treatment aiming at improving regeneration of infected neurons to prevent sequelae caused by ZIKV infection of fetus. (C) 2017 The Authors. Published by Elsevier B.V.
[1]Fudan Univ, State Key Lab Med Neurobiol, Collaborat Innovat Ctr Brain Sci,Minist Educ, Minist Hlth,Inst Brain Sci,Key Lab Med Mol Virol, Shanghai 200032, Peoples R China.
[2]Fudan Univ, Shanghai Publ Hlth Clin Ctr, Shanghai 200032, Peoples R China.
[3]Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, 600 Wan Ping Nan Rd, Shanghai 200030, Peoples R China.
[4]Nanjing Univ, Sch Life Sci, Dept Biol Sci & Technol, State Key Lab Pharmaceut Biotechnol, 163 Xianlin Ave, Nanjing 210023, Jiangsu, Peoples R China.
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