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Design, Synthesis, and Biological Evaluation of Novel Dual Inhibitors of Secretory Phospholipase A2 and Sphingomyelin Synthase 期刊论文

编号：

b79d0285-2451-43e9-a0c2-3fddbf4a079f
作者：

Gao, Xing^[1];Gong, Haojun^[1];Men, Peng^[1];Zhou, Lu(周璐)*^[1]Ye, Deyong(叶德泳)^[1]
语种：

English
期刊：

CHINESE JOURNAL OF CHEMISTRY ISSN：1001-604X 2013 年 31 卷 9 期 (1164 - 1170) ; SEP
收录：
关键词：

atherosclerosis secretory phospholipase A2 (sPLA2) sphingomyelin synthase (SMS) multi-target drug design dual inhibitors
摘要：

A novel series of eight SMS and sPLA2 dual inhibitors containing indole and -amino cyanide fragments of different length and substitution position was synthesized and evaluated by three different in vitro assays. Biological evaluation showed that all compounds provided inhibitory effects against SMS (about 50% inhibition at 100 mu mol/L) and sPLA2 (14-32 mu mol/L). All the compounds had the SMS activity better than the positive control compound D609 in SMS2 homogenate, with compounds 5b and 5e ideal for liver homogenate and SMS2 high expression cell homogenate, respectively.
推荐引用方式
GB/T 7714：

Gao Xing,Gong Haojun,Men Peng, et al. Design, Synthesis, and Biological Evaluation of Novel Dual Inhibitors of Secretory Phospholipase A2 and Sphingomyelin Synthase [J].CHINESE JOURNAL OF CHEMISTRY,2013,31(9):1164-1170.
APA：

Gao Xing,Gong Haojun,Men Peng,Zhou Lu,&Ye Deyong.(2013).Design, Synthesis, and Biological Evaluation of Novel Dual Inhibitors of Secretory Phospholipase A2 and Sphingomyelin Synthase .CHINESE JOURNAL OF CHEMISTRY,31(9):1164-1170.
MLA：

Gao Xing, et al. "Design, Synthesis, and Biological Evaluation of Novel Dual Inhibitors of Secretory Phospholipase A2 and Sphingomyelin Synthase" .CHINESE JOURNAL OF CHEMISTRY 31,9(2013):1164-1170.

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