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Signatures of positive selection at hemopexin (PEX) domain of matrix metalloproteinase-9 (MMP-9) gene 期刊论文

编号：

b7fc0119-5658-436d-af07-5469b5c54be9
作者：

Liu, Yang^[1] Zhao, Yang^[2] Lu, Chunlei^[3] Fu, Maobin^[2] Dou, Tonghai^[2] Tan, Xiaoming^[4]
语种：

English
期刊：

JOURNAL OF BIOSCIENCES ISSN：0250-5991 2015 年 40 卷 5 期 (885 - 890) ; DEC
收录：
关键词：

Adaptive evolution hemopexin Ka/Ks MMP-9 positive selection
摘要：

Matrix metalloproteinases-9 (MMP-9) is an important cancer-associated, zinc-dependent endopeptidase. To investigate the natural selection hypothesis of MMP-9, the orthologous sequences from 12 vertebrates were compared and a molecular evolution analysis was performed. Results suggest that amino acid residues present in the middle region of the protein are more selectively constrained, whereas amino acid residues in the C-terminal region of the MMP-9 protein including exon 13 showed lowest conservation level in non-primate species, suggesting that it is an exon with fast evolving rate compared to the others analyzed. InterProScan analysis shows that exon 13 was located in hemopexin (PEX) domain of MMP-9. Positive selection was detected in PEX domain of MMP-9 protein between human and other species, which indicates that selective pressure may play a role in shaping the function of MMP-9 in the course of evolution.
推荐引用方式
GB/T 7714：

Liu Yang,Zhao Yang,Lu Chunlei, et al. Signatures of positive selection at hemopexin (PEX) domain of matrix metalloproteinase-9 (MMP-9) gene [J].JOURNAL OF BIOSCIENCES,2015,40(5):885-890.
APA：

Liu Yang,Zhao Yang,Lu Chunlei,Fu Maobin,&Tan Xiaoming.(2015).Signatures of positive selection at hemopexin (PEX) domain of matrix metalloproteinase-9 (MMP-9) gene .JOURNAL OF BIOSCIENCES,40(5):885-890.
MLA：

Liu Yang, et al. "Signatures of positive selection at hemopexin (PEX) domain of matrix metalloproteinase-9 (MMP-9) gene" .JOURNAL OF BIOSCIENCES 40,5(2015):885-890.

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