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Development of A Reference Dose for BDE-47, 99, and 209 Using Benchmark Dose Methods 期刊论文

编号：

b82ab54c-a6d4-4f2c-9b72-104c5bc31957
作者：

Li Lu Xi^[1];Chen Li(陈丽)^[2]Cao Dan^[1];Chen Bing Heng(陈秉衡)^[1]Zhao Yan(赵岩)^[1]Meng Xiang Zhou^[3];Xie Chang Ming^[1];Zhang Yun Hui(张蕴晖)*^[1]
语种：

English
期刊：

BIOMEDICAL AND ENVIRONMENTAL SCIENCES ISSN：0895-3988 2014 年 27 卷 9 期 (733 - 739) ; SEP
收录：
摘要：

Eleven recently completed toxicological studies were critically reviewed to identify toxicologically significant endpoints and dose-response information. Dose-response data were compiled and entered into the USEPA's benchmark dose software (BMDS) for calculation of a benchmark dose (BMD) and a benchmark dose low (BMDL). After assessing 91 endpoints across the nine studies, a total of 23 of these endpoints were identified for BMD modeling, and BMDL estimates corresponding to various dose-response models were compiled for these separate endpoints. Thyroid, neurobehavior and reproductive endpoints for BDE-47, -99, -209 were quantitatively evaluated. According to methods and feature of each study, different uncertainty factor (UF) value was decided and subsequently reference doses (RfDs) were proposed. Consistent with USEPA, the lowest BMDLs of 2.10, 81.77, and 1698 mu g/kg were used to develop RfDs for BDE-47, -99, and -209, respectively. RfDs for BDE-99 and BDE-209 were comparable to EPA results, and however, RfD of BDE-47 was much lower than that of EPA, which may result from that reproductive/developmental proves to be more sensitive than neurobehavior for BDE-47 and the principal study uses very-low-dose exposure.
推荐引用方式
GB/T 7714：

Li Lu Xi,Chen Li,Cao Dan, et al. Development of A Reference Dose for BDE-47, 99, and 209 Using Benchmark Dose Methods [J].BIOMEDICAL AND ENVIRONMENTAL SCIENCES,2014,27(9):733-739.
APA：

Li Lu Xi,Chen Li,Cao Dan,Chen Bing Heng,&Zhang Yun Hui.(2014).Development of A Reference Dose for BDE-47, 99, and 209 Using Benchmark Dose Methods .BIOMEDICAL AND ENVIRONMENTAL SCIENCES,27(9):733-739.
MLA：

Li Lu Xi, et al. "Development of A Reference Dose for BDE-47, 99, and 209 Using Benchmark Dose Methods" .BIOMEDICAL AND ENVIRONMENTAL SCIENCES 27,9(2014):733-739.

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