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Genome-wide screening reveals that miR-195 targets the TNF-伪/NF-魏B pathway by down-regulating I魏B kinase alpha and TAB3 in hepatocellular carcinoma 期刊论文

编号：

bba0a85e-cf41-4550-bb38-1d24dd88bc97
作者：

Ding, Jie[0]^[1] Huang, Shenglin[1]^[2] Wang, Ying[2]^[3] Tian, Qi[3]^[3] Zha, Ruopeng[4]^[3] Shi, Haibing[5]^[3] Wang, Qifeng[6]^[3] Ge, Chao[7]^[3] Chen, Taoyang[8]^[4] Zhao, Yingjun[9]^[2] Liang, Linhui[10]^[2] Li, Jinjun[11]^[5] He, Xianghuo[12]^[2]
地址：

[1]The Affiliated DrumTower Hospital of Nanjing University Medical School, Department of General Surgery,Nanjing,China
[2]Fudan University Shanghai Medical College,Shanghai,China
[3]Renji Hospital, State Key Laboratory of Oncogenes and Related Genes,Shanghai,China
[4]Qidong Liver Cancer Institute,Qidong,China
[5]Capital Medical University China, Department of Orthopaedics,Beijing,China
语种：

英文
期刊：

Hepatology ISSN：0270-9139 2013 年 58 卷 2 期 (654 - 666)
收录：
摘要：

Nuclear factor kappa B (NF-κB) is an important factor linking inflammation and tumorigenesis. In this study we experimentally demonstrated through a high-throughput luciferase reporter screen that NF-κB signaling can be directly targeted by nearly 29 microRNAs (miRNAs). Many of these miRNAs can directly target NF-κB signaling nodes by binding to their 3′ untranslated region (UTR). miR-195, a member of the miR-15 family, is frequently down-regulated in gastrointestinal cancers, especially in hepatocellular carcinoma (HCC). The expression level of miR-195 is inversely correlated with HCC tumor size. We further show that miR-195 suppresses cancer cell proliferation and migration in vitro and reduces tumorigenicity and metastasis in vivo. Additionally, miR-195 may exert its tumor suppressive function by decreasing the expression of multiple NF-κB downstream effectors by way of the direct targeting of IKKα and TAB3. Conclusion: Multiple miRNAs are involved in the NF-κB signaling pathway and miR-195 plays important inhibitory roles in cancer progression and may be a potential therapeutic target. © 2013 by the American Association for the Study of Liver Diseases.
推荐引用方式
GB/T 7714：

Ding Jie/55697817000[0],Huang Shenglin/55810243600[1],Wang Ying/55860496200[2], et al. Genome-wide screening reveals that miR-195 targets the TNF-伪/NF-魏B pathway by down-regulating I魏B kinase alpha and TAB3 in hepatocellular carcinoma [J].Hepatology,2013,58(2):654-666.
APA：

Ding Jie/55697817000[0],Huang Shenglin/55810243600[1],Wang Ying/55860496200[2],Tian Qi/35103684100[3],&He Xianghuo/24465211300[12].(2013).Genome-wide screening reveals that miR-195 targets the TNF-伪/NF-魏B pathway by down-regulating I魏B kinase alpha and TAB3 in hepatocellular carcinoma .Hepatology,58(2):654-666.
MLA：

Ding Jie/55697817000[0], et al. "Genome-wide screening reveals that miR-195 targets the TNF-伪/NF-魏B pathway by down-regulating I魏B kinase alpha and TAB3 in hepatocellular carcinoma" .Hepatology 58,2(2013):654-666.

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