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Significance of PIVKA-II levels for predicting microvascular invasion and tumor cell proliferation in Chinese patients with hepatitis B virus-associated hepatocellular carcinoma 期刊论文

编号：

bd561cfd-1182-4155-896a-639abb9fd477
作者：

Ma, XiaoLu(马晓路)^[1]Zhu, Jing^[1];Wu, Jiong(吴炯)^[1]Tian, Lu^[1];Gao, YaoYi^[1];Zhang, ChunYan(张春燕)^[1]Zhou, Yan(周琰)^[1]Dai, Qian(戴谦)^[1]Wang, BeiLi(王蓓丽)^[1]Pan, BaiShen(潘柏申)^[1]Zhou, Jian(周俭)^[2]Fan, Jia(樊嘉)^[2]Yang, XinRong(杨欣荣)*^[2]Guo, Wei(郭玮)^[1]
语种：

English
期刊：

ONCOLOGY LETTERS ISSN：1792-1074 2018 年 15 卷 6 期 (8396 - 8404) ; JUN
收录：
关键词：

hepatocellular carcinoma PIVKA-II microvascular invasion proliferation Ki67
摘要：

The present study aimed to determine the levels of prothrombin induced by vitamin K absence-II (PIVKA-II) according to the Barcelona Clinic Liver Cancer (BCLC) staging system, to develop an appropriate strategy for managing hepatocellular carcinoma (HCC), particularly early HCC, and to investigate the value of PIVKA-II for predicting prognosis-associated pathological parameters. Clinical information of 117 patients with hepatitis B-associated HCC was retrospectively collected. Preoperative serum PIVKA-II and a-fetoprotein (AFP) levels were measured using a chemiluminescence method. The efficiency of PIVKA-II levels for predicting pathological parameters was evaluated using step-wise logistic regression. The receiver operator characteristic curve was used to evaluate the predictive performance of PIVKA-II levels. It was demonstrated that except for the difference between stages B and C HCC (P=0.923), serum PIVKA-II levels significantly increased according to BCLC stage (P<0.050), however AFP levels did not. In early HCC (stage 0+A), the correlation between PIVKA-II and AFP levels (dual-positive, 64.70% in stage 0; 46.97% in stage A) was relatively weak (r=0.410). PIVKA-II >40 mAU/ml was an independent predictor of microvascular invasion [hazard ratio (HR), 3.77; 95% confidence interval (CI), 1.31-10.88; P=0.014; and high Ki67 expression in situ (HR, 2.99; 95% CI, 1.19-7.52; P=0.020). Combined analysis of PIVKA and AFP levels may contribute to an effective strategy for the management of patients with early HCC, as high PIVKA-II levels indicated a more aggressive tumor phenotype. Further investigation of PIVKA-II levels may provide novel insights into the mechanism underlying the metastasis of HCC cells and facilitate the development of novel therapeutic strategies for HCC.
推荐引用方式
GB/T 7714：

Ma Xiao-Lu,Zhu Jing,Wu Jiong, et al. Significance of PIVKA-II levels for predicting microvascular invasion and tumor cell proliferation in Chinese patients with hepatitis B virus-associated hepatocellular carcinoma [J].ONCOLOGY LETTERS,2018,15(6):8396-8404.
APA：

Ma Xiao-Lu,Zhu Jing,Wu Jiong,Tian Lu,&Guo Wei.(2018).Significance of PIVKA-II levels for predicting microvascular invasion and tumor cell proliferation in Chinese patients with hepatitis B virus-associated hepatocellular carcinoma .ONCOLOGY LETTERS,15(6):8396-8404.
MLA：

Ma Xiao-Lu, et al. "Significance of PIVKA-II levels for predicting microvascular invasion and tumor cell proliferation in Chinese patients with hepatitis B virus-associated hepatocellular carcinoma" .ONCOLOGY LETTERS 15,6(2018):8396-8404.

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