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Effects of DNA repair gene polymorphisms on DNA damage in human lymphocytes induced by a vinyl chloride metabolite in vitro 期刊论文

编号：

bee2b8fe-0a65-4716-a4d1-7c0c05f31c47
作者：

Feng, Nannan(冯楠楠)#^[1,2]Li, Yongliang^[2];Long, Changmin^[2];Xia, Zhaolin(夏昭林)^[1]BrandtRauf, Paul W.^[2];
语种：

English
期刊：

BIOMARKERS ISSN：1354-750X 2014 年 19 卷 4 期 (281 - 286) ; JUN
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关键词：

DNA repair micronuclei polymorphisms
摘要：

Background: Epidemiologic studies suggest that variability in DNA damage from vinyl chloride monomer (VCM) may be partially mediated by genetic polymorphisms in DNA repair. This study aimed to corroborate these observations with controlled experiments in vitro using cell lines from individuals with differing DNA repair genotypes to determine damage following VCM metabolite exposure. Methods: Matched pairs of lymphoblast cell lines (homozygous wild-type versus homozygous variant for either XRCC1 399 or XPD 751 polymorphism) were exposed to chloroacetaldehyde and analyzed by the cytokinesis-block micronucleus assay. Results: All cell lines demonstrated a dose-response of increasing micronuclei with increasing exposure, but for both XRCC1 and XPD, the polymorphic cells peaked at higher micronucleus frequencies and declined at a slower rate to baseline than the wild-type cells. Conclusion: This supports the findings that XRCC1 and XPD polymorphisms may result in deficient DNA repair of VCM-induced genetic damage.
推荐引用方式
GB/T 7714：

Feng Nannan,Li Yongliang,Long Changmin, et al. Effects of DNA repair gene polymorphisms on DNA damage in human lymphocytes induced by a vinyl chloride metabolite in vitro [J].BIOMARKERS,2014,19(4):281-286.
APA：

Feng Nannan,Li Yongliang,Long Changmin,Xia Zhao-lin,&Brandt-Rauf Paul W..(2014).Effects of DNA repair gene polymorphisms on DNA damage in human lymphocytes induced by a vinyl chloride metabolite in vitro .BIOMARKERS,19(4):281-286.
MLA：

Feng Nannan, et al. "Effects of DNA repair gene polymorphisms on DNA damage in human lymphocytes induced by a vinyl chloride metabolite in vitro" .BIOMARKERS 19,4(2014):281-286.

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