首页 / 院系成果 / 成果详情页

Mycobacterial Lipoprotein Z Triggers Efficient Innate and Adaptive Immunity for Protection Against Mycobacterium tuberculosis Infection 期刊论文

编号：

beff3558-4c02-42dd-aa70-41b501e6a399
作者：

Chen, Yingying#^[1]Xiao, Jiani#^[1]Li, Yong#^[1]Xiao, Yangjiong#^[1]Xiong, Yanqing^[2];Liu, Ying^[1];Wang, Shujun^[1];Ji, Ping^[1];Zhao, Guoping^[3];Shen, Hao^[1,4];Lu, Shuihua(卢水华)^[2]Fan, Xiaoyong(范小勇)*^[2,5]Wang, Ying*^[1,3]
语种：

英文
期刊：

FRONTIERS IN IMMUNOLOGY ISSN：1664-3224 2019 年 9 卷 ; JAN 16
收录：
关键词：

lipoprotein Z tuberculosis innate immunity T cell immunity immune protection
摘要：

Mycobacterial lipoproteins are considered to be involved in both virulence and immunoregulatory processes during Mycobacterium tuberculosis (M. tb) infection. In our previous investigations on the immunoreactivity of more than 30 M. tb proteins in active TB patients, we identified mycobacterial lipoprotein Z (LppZ) as one of the most immune dominant antigens. How LppZ triggers immune responses is still unclear. In this study, we analyzed LppZ-mediated innate and adaptive immunity using a murine air pouch model and an M. tb infection model, respectively. We found that LppZ could not only recruit inflammatory cells but also induce the production of proinflammatory cytokines inside the pouches. LppZ could also induce strong Th1 responses following immunization and confer protection against challenge with M. tb virulent strain H37Rv at a similar level to BCG vaccination but with less pathological damage in the lungs. Furthermore, we revealed the presence of LppZ-specific functional CD4(+) T cells in the lungs of the challenged mice that were capable of secreting double or triple cytokines, including IFN-gamma, IL-2, and TNF-alpha. Our study thus demonstrates that LppZ is of strong immunogenicity during M. tb infection in both humans and mice and has the ability to trigger effective innate and cellular immunity. Considering the limitations of candidate antigens in the pipeline of TB vaccine development, LppZ-mediated immune protection against M. tb challenge in the mouse model implies its potential application in vaccine development.
推荐引用方式
GB/T 7714：

Chen Yingying,Xiao Jia-ni,Li Yong, et al. Mycobacterial Lipoprotein Z Triggers Efficient Innate and Adaptive Immunity for Protection Against Mycobacterium tuberculosis Infection [J].FRONTIERS IN IMMUNOLOGY,2019,9.
APA：

Chen Yingying,Xiao Jia-ni,Li Yong,Xiao Yang-jiong,&Wang Ying.(2019).Mycobacterial Lipoprotein Z Triggers Efficient Innate and Adaptive Immunity for Protection Against Mycobacterium tuberculosis Infection .FRONTIERS IN IMMUNOLOGY,9.
MLA：

Chen Yingying, et al. "Mycobacterial Lipoprotein Z Triggers Efficient Innate and Adaptive Immunity for Protection Against Mycobacterium tuberculosis Infection" .FRONTIERS IN IMMUNOLOGY 9(2019).
条目包含文件：

文件类型：PDF,文件大小：

正在加载全文

未找到全文

浏览次数：65  下载次数：0

分享到：

浏览次数：65

下载次数：0

打印次数：0