首页 / 院系成果 / 成果详情页

Increased peripheral and local soluble FGL2 in the recovery of renal ischemia reperfusion injury in a porcine kidney auto-transplantation model 期刊论文

编号：

bf1b7141-0fbc-488f-8804-100b7b8a874f
作者：

Zhao, Zitong(赵梓彤)#^[1,2]Yang, Cheng(杨橙)^[1,2]Li, Long(李龙)^[1,2]Zhao, Tian(赵天)^[1,2]Wang, Lingyan^[4];Rong, Ruiming(戎瑞明)^[1,2,5]Yang, Bin^[3];Xu, Ming(许明)^[1,2]Zhu, Tongyu(朱同玉)^[1,2,6]
语种：

English
期刊：

JOURNAL OF TRANSLATIONAL MEDICINE ISSN：1479-5876 2014 年 12 卷 ; FEB 23
收录：
关键词：

Soluble FGL2 Ischemia reperfusion injury Kidney auto-transplantation Porcine Fc gamma RIIB
摘要：

Background: Regulatory T cells (Treg) protect kidney against ischemia reperfusion (IR) injury via suppressing innate immunity, but the mechanism has not been fully clarified. Soluble fibrinogen-like protein 2 (sFGL2), a novel effector of Treg, may affect apoptosis and inflammation. This study investigated the role of sFGL2 in renal IR injury in a porcine kidney auto-transplantation model. Materials and methods: The left kidney was retrieved from mini pigs and infused by University of Wisconsin solution into the renal artery with the renal artery and vein clamped for 24-h cold storage. After the right nephrectomy, the left kidney was auto-transplanted into the right for 2 weeks. 3 pigs were sacrificed at day 2, 5, 7, 10 and 14 post-transplantation respectively. Collected renal tissues and daily blood samples were stored for further analyses. Results: Both serum creatinine and blood urea nitrogen were maximized during day 2 to 5 and followed by a gradual recovery over 2 weeks. The similar pattern were showed in histological damage, myeloperoxidase + cells and apoptosis in the kidney, as well as circulating TNF-alpha and IFN-gamma. Serum sFGL2 presented a fluctuating increase and reached a peak at day 10. The expression of sFGL2 and its receptor Fc gamma RIIB as well as Foxp3 and IL-10 in the kidney was notably increased from day 5 to 10. Conclusion: The increased sFGL2 together with Fc gamma RIIB during renal recovery after IR injury suggested that sFGL2 might be a potential renoprotective mediator involved in the renal self-repairing and remodeling in this 2-week porcine auto-transplantation model.
推荐引用方式
GB/T 7714：

Zhao Zitong,Yang Cheng,Li Long, et al. Increased peripheral and local soluble FGL2 in the recovery of renal ischemia reperfusion injury in a porcine kidney auto-transplantation model [J].JOURNAL OF TRANSLATIONAL MEDICINE,2014,12.
APA：

Zhao Zitong,Yang Cheng,Li Long,Zhao Tian,&Zhu Tongyu.(2014).Increased peripheral and local soluble FGL2 in the recovery of renal ischemia reperfusion injury in a porcine kidney auto-transplantation model .JOURNAL OF TRANSLATIONAL MEDICINE,12.
MLA：

Zhao Zitong, et al. "Increased peripheral and local soluble FGL2 in the recovery of renal ischemia reperfusion injury in a porcine kidney auto-transplantation model" .JOURNAL OF TRANSLATIONAL MEDICINE 12(2014).

浏览次数：1  下载次数：0

分享到：

浏览次数：1

下载次数：0

打印次数：0