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Performance of the Prostate Health Index in predicting prostate biopsy outcomes among men with a negative digital rectal examination and transrectal ultrasonography 期刊论文

编号：

bff7caf1-7eaf-4b97-bd87-6ae4313e65c3
作者：

Yu, GuoPeng^[1,2];Na, Rong(那溶)^[1,2]Ye, DingWei(叶定伟)^[3,4]Qi, Jun^[5];Liu, Fang^[1,6,7];Chen, HaiTao^[6];Wu, YiShuo(吴亦硕)^[1,2]Zhang, GuiMing^[3,4];Sun, JieLin^[7];Zhu, Yao(朱耀)^[3,4]Huang, LiQun^[5];Ren, ShanCheng^[8];Jiang, DeKe^[6,9];Zheng, S. Lilly^[7,9];Jiang, HaoWen(姜昊文)^[1,2]Sun, YingHao^[8];Ding, Qiang(丁强)*^[1,2]Xu, Jianfeng^[1,2,6,9];
语种：

English
期刊：

ASIAN JOURNAL OF ANDROLOGY ISSN：1008-682X 2016 年 18 卷 4 期 (633 - 638) ; JUL-AUG
收录：
关键词：

[-2]proPSA prostate cancer Prostate Health Index prostate-specific antigen receiver operating curve
摘要：

The [-2]proPSA (p2PSA) and its derivatives, the p2PSA-to-free PSA ratio (%p2PSA), and the Prostate Health Index (PHI) have greatly improved discrimination between men with and without prostate cancer (PCa) in prostate biopsies. However, little is known about their performance in cases where a digital rectal examination (DRE) and transrectal ultrasonography (TRUS) are negative. A prospective cohort of 261 consecutive patients in China with negative DRE and TRUS were recruited and underwent prostate biopsies. A serum sample had collected before the biopsy was used to measure various PSA derivatives, including total prostate-specific antigen (tPSA), free PSA, and p2PSA. For each patient, the free-to-total PSA ratio (%fPSA), PSA density (PSAD), p2PSA-to-free PSA ratio (%p2PSA), and PHI were calculated. Discriminative performance was assessed using the area under the receiver operating characteristic curve (AUC) and the biopsy rate at 91% sensitivity. The AUC scores within the entire cohort with respect to age, tPSA, %fPSA, PSAD, p2PSA, % p2PSA, and PHI were 0.598, 0.751, 0.646, 0.789, 0.814, 0.808, and 0.853, respectively. PHI was the best predictor of prostate biopsy results, especially in patients with a tPSA of 10.1-20 ng ml(-1). Compared with other markers, at a sensitivity of 91%, PHI was the most useful for determining which men did not need to undergo biopsy, thereby avoiding unnecessary procedures. The use of PHI could improve the accuracy of PCa detection by predicting prostate biopsy outcomes among men with a negative DRE and TRUS in China.
推荐引用方式
GB/T 7714：

Yu Guo-Peng,Na Rong,Ye Ding-Wei, et al. Performance of the Prostate Health Index in predicting prostate biopsy outcomes among men with a negative digital rectal examination and transrectal ultrasonography [J].ASIAN JOURNAL OF ANDROLOGY,2016,18(4):633-638.
APA：

Yu Guo-Peng,Na Rong,Ye Ding-Wei,Qi Jun,&Xu Jianfeng.(2016).Performance of the Prostate Health Index in predicting prostate biopsy outcomes among men with a negative digital rectal examination and transrectal ultrasonography .ASIAN JOURNAL OF ANDROLOGY,18(4):633-638.
MLA：

Yu Guo-Peng, et al. "Performance of the Prostate Health Index in predicting prostate biopsy outcomes among men with a negative digital rectal examination and transrectal ultrasonography" .ASIAN JOURNAL OF ANDROLOGY 18,4(2016):633-638.

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