首页 / 院系成果 / 成果详情页

Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs 期刊论文 WOS高被引论文

编号：

c0836535-58a8-430c-bc7d-7cee446df2e5
作者：

Zheng, Qiupeng^[1,2,3,4];Bao, Chunyang^[1,2,3];Guo, Weijie^[1,2,3,4];Li, Shuyi^[1,2,3,4];Chen, Jie^[1,2,3];Chen, Bing^[1,2,3];Luo, Yanting^[1,2,3];Lyu, Dongbin^[1,2,3];Li, Yan(李延)^[1,2,3]Shi, Guohai(施国海)^[1,2,3]Liang, Linhui(梁琳慧)^[1,2,3]Gu, Jianren^[4];He, Xianghuo(何祥火)*^[1,2,3]Huang, Shenglin(黄胜林)*^[1,2,3]
语种：

英文
期刊：

NATURE COMMUNICATIONS ISSN：2041-1723 2016 年 7 卷 ; APR
收录：
摘要：

Circular RNAs (circRNAs) represent a class of widespread and diverse endogenous RNAs that may regulate gene expression in eukaryotes. However, the regulation and function of human circRNAs remain largely unknown. Here we generate ribosomal-depleted RNA sequencing data from six normal tissues and seven cancers, and detect at least 27,000 circRNA candidates. Many of these circRNAs are differently expressed between the normal and cancerous tissues. We further characterize one abundant circRNA derived from Exon2 of the HIPK3 gene, termed circHIPK3. The silencing of circHIPK3 but not HIPK3 mRNA significantly inhibits human cell growth. Via a luciferase screening assay, circHIPK3 is observed to sponge to 9 miRNAs with 18 potential binding sites. Specifically, we show that circHIPK3 directly binds to miR-124 and inhibits miR-124 activity. Our results provide evidence that circular RNA produced from precursor mRNA may have a regulatory role in human cells.
推荐引用方式
GB/T 7714：

Zheng Qiupeng,Bao Chunyang,Guo Weijie, et al. Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs [J].NATURE COMMUNICATIONS,2016,7.
APA：

Zheng Qiupeng,Bao Chunyang,Guo Weijie,Li Shuyi,&Huang Shenglin.(2016).Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs .NATURE COMMUNICATIONS,7.
MLA：

Zheng Qiupeng, et al. "Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs" .NATURE COMMUNICATIONS 7(2016).
条目包含文件：

文件类型：PDF,文件大小：

正在加载全文

未找到全文

浏览次数：694  下载次数：0

分享到：

浏览次数：694

下载次数：0

打印次数：0