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The minimum LOH region defined on chromosome 17p13.3 in human hepatocellular carcinoma with gene content analysis 期刊论文

编号：

c0b41ee4-a232-4faa-a8ba-8c1e641fec69
作者：

Zhao, Xintai[0]^[1] He, Mei[1]^[2] Wan, Dafang[2]^[3] Ye, Yun[3]^[2] He, Yinghua[4]^[4] Han, Liwei[5]^[5] Guo, Minglei[6]^[6] Huang, Y.[7]^[7] Qin, Wenxin[8]^[8] Wang, Mingwei[9]^[9] Chong, Wenming[10]^[10] Chen, Jianguo[11]^[11] Zhang, Lisheng[12]^[12] Yang, Nanwu[13]^[13] Xu, Binghua[14]^[14] Wu, Mengchao[15]^[15] Zuo, Lin[16]^[2] Gu, Jianren[17]^[16]
地址：

[1]s Republic of China, Technical Department,Beijing,China
[2]Shanghai GeneCore B. C.,Shanghai,China
[3]Shanghai Jiaotong University, State Key Laboratory of Oncogenes and Related Genes,Shanghai,China
[4]Renji Hospital, Cancer Epigenetics Program,Shanghai,China
[5]Medical Center of Fudan University, Natl. Laboratory of Oncogenes/R. G.,Shanghai,China
[6]Medical Center of Fudan University, Shanghai Cancer Institute,Shanghai,China
[7]University of Liverpool, Department of Electrical and Electronic Engineering,Liverpool,United Kingdom
[8]Renji Hospital, School of Medicine,Shanghai,China
[9]Fudan University, Center for Biomedical Imaging,Shanghai,China
[10]E. Hepatobiliary Surgery Hospital,Shanghai,China
[11]Huazhong University of Science and Technology, Department of Pharmacology,Wuhan,China
[12]Institute of Computing Technology Chinese Academy of Sciences,Beijing,China
[13]Guangxi Medical University, Department of Gastroenteritis and Breast,Nanning,China
[14]Qidong Liver Cancer Institute,Qidong,China
[15]Eastern Hepatobiliary Surgery Hospital, Department of Hepatic Surgery,Shanghai,China
[16]Renji Hospital, Shanghai Cancer Institute,Shanghai,China
Scopus被引频次：

23 次
语种：

英文
期刊：

Cancer Letters ISSN：0304-3835 2003 年 190 卷 2 期 (221 - 232)
收录：
关键词：

17p13.3 CDNA Gene annotation Hepatocellular carcinoma Loss of heterozygosity Sequence analysis
摘要：

Hepatocellular carcinoma (HCC) is one of the most common human cancers in Asia. Previous studies have shown that in addition to aberrations of the p53 gene on chromosome 17p13.1, other gene(s) on chromosome 17p13.3 may also play a role in HCC. To detect the status of loss of heterozygosity (LOH) in HCC and to determine the minimum region of LOH on 17p13.3, we analyzed 22 paired HCC and non-cancerous liver samples with 14 polymorphic markers plus TP53 (p53 gene) as a comparison. The data revealed a high level of LOH (>68%) in a minimum region between D17S1866 and D17S1574, spanning over a 1.5 Mb region. Genomic library screening using markers in the region has resulted in the isolation of a cluster of BAC/PAC clones. We created a physical map in this region. Using large-scale genome sequencing, gene annotation, cDNA screening, and exon trapping, we identified 17 known genes and 13 novel genes in the minimum region. The function of these genes was analyzed and the possibility of several putative tumor suppressor genes was discussed. © 2002 Elsevier Science Ireland Ltd. All rights reserved.
推荐引用方式
GB/T 7714：

Zhao Xintai/7407576163[0],He Mei/57188562801[1],Wan Dafang/7103411687[2], et al. The minimum LOH region defined on chromosome 17p13.3 in human hepatocellular carcinoma with gene content analysis [J].Cancer Letters,2003,190(2):221-232.
APA：

Zhao Xintai/7407576163[0],He Mei/57188562801[1],Wan Dafang/7103411687[2],Ye Yun/7401627819[3],&Gu Jianren/7403129786[17].(2003).The minimum LOH region defined on chromosome 17p13.3 in human hepatocellular carcinoma with gene content analysis .Cancer Letters,190(2):221-232.
MLA：

Zhao Xintai/7407576163[0], et al. "The minimum LOH region defined on chromosome 17p13.3 in human hepatocellular carcinoma with gene content analysis" .Cancer Letters 190,2(2003):221-232.

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