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Efficacy of ACE inhibitors in chronic heart failure with preserved ejection fraction - A meta analysis of 7 prospective clinical studies 期刊论文

编号：

c0b62001-b162-4393-a261-90fa102f2c7d
作者：

Fu, Mingqiang(付明强)#^[1]Zhou, Jingmin(周京敏)^[1]Sun, Aijun(孙爱军)^[1,2]Zhang, Shuning^[1];Zhang, Chunyu^[1];Zou, Yunzeng(邹云增)^[1,2]Fu, Michael^[3];Ge, Junbo(葛均波)*^[1,2]
语种：

English
期刊：

INTERNATIONAL JOURNAL OF CARDIOLOGY ISSN：0167-5273 2012 年 155 卷 1 期 (33 - 38) ; FEB 23
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关键词：

ACEI Heart failure Preserved systolic function Meta analysis
摘要：

Background: The effect of ACE inhibitors on the prognosis of chronic heart failure patients with preserved left ventricular ejection fraction remains controversial. Aims: To assess the impact of ACE inhibitors on the prognosis of chronic heart failure patients with preserved left ventricular ejection fraction. Methods and results: Seven prospective studies evaluating the effect of ACE inhibitors compared to placebo or other classes of drugs, such as monotherapy or first-line therapy, on the prognosis of chronic heart failure patients with preserved left ventricular ejection fraction were included. A total of 2554 patients (mean age: 75.1 years, female: 58%) were recruited with an average follow up of 20.9 months. The primary etiology of heart failure with preserved ejection fraction was ischemic heart disease (33.7%), hypertension (69.1%) and diabetes mellitus (25.8%). Our results demonstrated that ACE inhibitors significantly reduced all-cause mortality (odds ratio, OR=0.52; 95% Confidence Interval (CI), 0.41 to 0.64; P<0.01). Furthermore, ACE inhibitors were able to reduce heart failure related rehospitalization or treatment over 20.9 months (p<0.05) in a subgroup of patients aged over 75 years. However, death due to worsening of heart failure, heart failure related rehospitalization and any-cause readmission were not affected (OR=0.88; 95% CI: 0.66 to 1.17; P=0.37 for death due to worsening of heart failure; OR=0.81; 95% CI: 0.63 to 1.05; P=0.11 for heart failure related rehospitalization and OR=0.88; 95% CI: 0.68 to 1.14; P=0.33 for any-cause readmission, respectively). Conclusions: In patients with chronic heart failure with preserved ejection fraction, ACE inhibitors reduced all-cause mortality without affecting mortality due to heart failure and any-cause rehospitalization. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
推荐引用方式
GB/T 7714：

Fu Mingqiang,Zhou Jingmin,Sun Aijun, et al. Efficacy of ACE inhibitors in chronic heart failure with preserved ejection fraction - A meta analysis of 7 prospective clinical studies [J].INTERNATIONAL JOURNAL OF CARDIOLOGY,2012,155(1):33-38.
APA：

Fu Mingqiang,Zhou Jingmin,Sun Aijun,Zhang Shuning,&Ge Junbo.(2012).Efficacy of ACE inhibitors in chronic heart failure with preserved ejection fraction - A meta analysis of 7 prospective clinical studies .INTERNATIONAL JOURNAL OF CARDIOLOGY,155(1):33-38.
MLA：

Fu Mingqiang, et al. "Efficacy of ACE inhibitors in chronic heart failure with preserved ejection fraction - A meta analysis of 7 prospective clinical studies" .INTERNATIONAL JOURNAL OF CARDIOLOGY 155,1(2012):33-38.

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