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A multifunctional nanotheranostic for the intelligent MRI diagnosis and synergistic treatment of hypoxic tumor 期刊论文

编号：

c0dec176-361d-4e39-9bd1-752debe5ca59
作者：

Song, Ruixue^[1];Zhang, Meng^[2];Liu, Yanyan^[1];Cui, Zhaowen^[2];Zhang, Hua(张华)^[3]Tang, Zhongmin^[2];Chen, Xiaoyan^[1];Wu, Haihong^[1];Yao, Zhenwei(姚振威)*^[3]He, Mingyuan^[1];Bu, Wenbo^[1,2];
语种：

English
期刊：

BIOMATERIALS ISSN：0142-9612 2018 年 175 卷 (123 - 133) ; AUG
收录：
关键词：

Hypoxia tumor Nanotheranostics Chemotherapy Magnetic resonance imaging Nanotechnology
摘要：

Hypoxia, as an inevitable characteristic of solid tumors, has been regarded as a noticeably causative factor to therapeutic resistance and metastatic variants. Exploring novel theranostics to realize the accurate diagnosis of hypoxia and the simultaneous implementation of effective therapy is a promising prospect for the successful treatment of tumors. In the present study, we designed and synthesized a multifunctional rattle-structured nanotheranostic, with the inner core coated by hollow mesoporous silica for chemical drug Doxorubicin (DOX) storage and hypoxia-sensitive MnO2 enrichment. In various acidic micro-environments caused by hypoxia, MnO2 nanosheets could be degraded into manganese ions (Mn2+), which were chelated by the modified Tetraxetanum (DOTA) ligands for real-time Ti-magnetic resonance imaging (T1-MRI), with on-demand DOX release to realize both normoxia and hypoxiasensitive chemotherapy by overcoming hypoxia. Nanotheranostics integrating hypoxia-driven T1-MRI with synergetic chemotherapy have tremendous potential in the intelligent diagnosis, personalized treatment and excellent prognosis of solid tumors in the future. (C) 2018 Elsevier Ltd. All rights reserved.
推荐引用方式
GB/T 7714：

Song Ruixue,Zhang Meng,Liu Yanyan, et al. A multifunctional nanotheranostic for the intelligent MRI diagnosis and synergistic treatment of hypoxic tumor [J].BIOMATERIALS,2018,175:123-133.
APA：

Song Ruixue,Zhang Meng,Liu Yanyan,Cui Zhaowen,&Bu Wenbo.(2018).A multifunctional nanotheranostic for the intelligent MRI diagnosis and synergistic treatment of hypoxic tumor .BIOMATERIALS,175:123-133.
MLA：

Song Ruixue, et al. "A multifunctional nanotheranostic for the intelligent MRI diagnosis and synergistic treatment of hypoxic tumor" .BIOMATERIALS 175(2018):123-133.

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