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Associations of prenatal exposure to five chlorophenols with adverse birth outcomes 期刊论文

编号：

c0e4dd06-b22a-4065-af5b-fbf20b4ab9a4
作者：

Guo, Jianqiu(郭剑秋)#^[1]Wu, Chunhua(邬春华)*^[1]Lv, Shenliang(吕沈亮)^[1,2]Lu, Dasheng^[1,2];Feng, Chao^[2];Qi, Xiaojuan(齐小娟)^[1,3]Liang, Weijiu^[4];Chang, Xiuli(常秀丽)^[1]Xu, Hao^[4];Wang, Guoquan^[2];Zhou, Zhijun(周志俊)^[1]
语种：

English
期刊：

ENVIRONMENTAL POLLUTION ISSN：0269-7491 2016 年 214 卷 (478 - 484) ; JUL
收录：
关键词：

Chlorophenols Prenatal exposure Birth outcomes Newborns Urine
摘要：

Exposures to chlorophenols (CPs) have been linked with adverse health effects on wildlife and humans. This study aimed to evaluate prenatal exposure to five CP compounds using maternal urinary concentrations during pregnancy and the potential associations with birth outcomes of their infants at birth. A total of 1100 mother-newborn pairs were recruited during June 2009 to January 2010 in an agricultural region, China. Urinary concentrations of five CPs from dichlorophenol (DCP) to pentachlorophenol (PCP), namely, 2,5-DCP, 2,4-DCP, 2,4,5-trichlorophenol (2,4,5-TCP), 2,4,6-TCP and PCP, were measured using large-volume-injection gas chromatography-tandem mass spectrometry (LVI-GC-MS-MS), and associations between CP levels and weight, length as well as head circumference at birth were examined. Median urinary creatinine-adjusted concentrations of 2,5-DCP, 2,4-DCP, 2,4,5-TCP, 2,4,6-TCP and PCP were 3.34 mu g/g, 1.03 mu g/g, < LOD, 1.78 mu g/g and 0.39 mu g/g creatinine, respectively. We found lower birth weight 30 g [95% confidence interval (CI): -57, -3; p = 0.03] for per SD increase in logio-transformed concentrations of 2,4,6-TCP and lower birth weight 37 g (95% CI: -64, -10; p = 0.04) for PCP, respectively. Similarly, head circumference decrease in associations with creatinine-corrected 2,4,6-TCP and PCP concentrations were also achieved. Considering sex difference, the associations of lower birth weight were only found among male neonates, while head circumference was associated with 2,4-DCP and 2,5-DCP only found among female neonates. This study showed significant negative associations between CPs exposure and reduction in neonatal anthropometric measures. The biological mechanisms concerning CPs exposure on fetal growth deserved further investigations. (C) 2016 Elsevier Ltd. All rights reserved.
推荐引用方式
GB/T 7714：

Guo Jianqiu,Wu Chunhua,Lv Shenliang, et al. Associations of prenatal exposure to five chlorophenols with adverse birth outcomes [J].ENVIRONMENTAL POLLUTION,2016,214:478-484.
APA：

Guo Jianqiu,Wu Chunhua,Lv Shenliang,Lu Dasheng,&Zhou Zhijun.(2016).Associations of prenatal exposure to five chlorophenols with adverse birth outcomes .ENVIRONMENTAL POLLUTION,214:478-484.
MLA：

Guo Jianqiu, et al. "Associations of prenatal exposure to five chlorophenols with adverse birth outcomes" .ENVIRONMENTAL POLLUTION 214(2016):478-484.

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