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Comparison of Gentamicin Distribution in the Inner Ear following Administration via the Endolymphatic Sac or Round Window 期刊论文

编号：

c10162a4-b555-4d9f-909f-25deeb2241fb
作者：

Zhang, Yiliang(张裔良)#^[1,2]Zhang, Ru^[3];Dai, Chunfu^[3,4];Steyger, Peter S.^[5];Yu, Yongfu(余勇夫)^[6]
语种：

English
期刊：

LARYNGOSCOPE ISSN：0023-852X 2010 年 120 卷 10 期 (2054 - 2060) ; OCT
收录：
关键词：

Gentamicin endolymphatic sac round window Meniere's disease
摘要：

Objective/Hypothesis: The distribution of gentamicin in the inner ear via the endolymphatic sac (ES) or round window (RW) routes was investigated. Study Design: Experimental study. Methods: A fluorescent gentamicin-Texas Red conjugate (GTTR) was adopted to visualize the gentamicin. Adult guinea pigs were treated with GTTR applied to the ES or RW, the animals were allowed to recover for 3 days, then confocal microscopy was used to observe and quantify GTTR distributions in cochlear and vestibular sensory epithelium. Results: When GTTR was applied via the ES, strong GTTR labeling was observed in the vestibule while little GTTR was detected in the cochlea (P < .0001). However, distinct GTTR fluorescence was observed in the cochlea and vestibule following RW application (P = .7967). There was less GTTR labeling in cochlea via ES application than through RW administration (P < .0001). Conclusions: ES drug application may be preferable for the treatment of intractable Meniere's disease.
推荐引用方式
GB/T 7714：

Zhang Yiliang,Zhang Ru,Dai Chunfu, et al. Comparison of Gentamicin Distribution in the Inner Ear following Administration via the Endolymphatic Sac or Round Window [J].LARYNGOSCOPE,2010,120(10):2054-2060.
APA：

Zhang Yiliang,Zhang Ru,Dai Chunfu,Steyger Peter S.,&Yu Yongfu.(2010).Comparison of Gentamicin Distribution in the Inner Ear following Administration via the Endolymphatic Sac or Round Window .LARYNGOSCOPE,120(10):2054-2060.
MLA：

Zhang Yiliang, et al. "Comparison of Gentamicin Distribution in the Inner Ear following Administration via the Endolymphatic Sac or Round Window" .LARYNGOSCOPE 120,10(2010):2054-2060.

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