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Evaluation of a recombinant BCG expressing antigen Ag85B and PPE protein Rv3425 from DNA segment RD11 of Mycobacterium tuberculosis in C57BL/6 mice 期刊论文

编号：

c1bedbca-7402-4a45-b96a-86779784aea9
作者：

Wang, Jiu Ling^[2];Qie, Ya Qing^[2];Zhu, Bing Dong^[3];Zhang, Hong Mei^[4];Xu, Ying^[2];Wang, Qing Zhong^[2];Chen, Jia Zhen(陈嘉臻)^[2]Liu, Wei^[2];Wang, Hong Hai^[1,2];
语种：

English
期刊：

MEDICAL MICROBIOLOGY AND IMMUNOLOGY ISSN：0300-8584 2009 年 198 卷 1 期 (5 - 11) ; FEB
收录：
关键词：

Mycobacterium tuberculosis Vaccine Ag85B Rv3425
摘要：

Antigen 85B (Ag85B) is an important immunodominant antigen of Mycobacterium tuberculosis, and is a very promising vaccine candidate molecule. Rv3425 is a member of the subgroup 3 of the PPE family, which does not exist in all BCG strains. In this study we constructed a new rBCG which included this united gene (Ag85B-Rv3425). The level of antigen-stimulated T cells expressing IFN-gamma was significantly higher in the C57BL/6 mice vaccinated with rBCG::Ag85B-Rv3425 than with BCG. In addition, the sera from mice immunized with rBCG::Ag85B-Rv3425 revealed an increase in the specific immunoglobulin G titers than that from mice immunized with BCG. Antigen specific IgG subclass analysis showed that rBCG::Ag85B-Rv3425 tended to facilitate IgG2a production, suggesting enhancement of predominant Th1 response which in turn may facilitate increased production of protective IFN-gamma. These results suggested that this rBCG::Ag85B-Rv3425 could be a strong vaccine candidate for further study.
推荐引用方式
GB/T 7714：

Wang Jiu Ling,Qie Ya Qing,Zhu Bing Dong, et al. Evaluation of a recombinant BCG expressing antigen Ag85B and PPE protein Rv3425 from DNA segment RD11 of Mycobacterium tuberculosis in C57BL/6 mice [J].MEDICAL MICROBIOLOGY AND IMMUNOLOGY,2009,198(1):5-11.
APA：

Wang Jiu Ling,Qie Ya Qing,Zhu Bing Dong,Zhang Hong Mei,&Wang Hong Hai.(2009).Evaluation of a recombinant BCG expressing antigen Ag85B and PPE protein Rv3425 from DNA segment RD11 of Mycobacterium tuberculosis in C57BL/6 mice .MEDICAL MICROBIOLOGY AND IMMUNOLOGY,198(1):5-11.
MLA：

Wang Jiu Ling, et al. "Evaluation of a recombinant BCG expressing antigen Ag85B and PPE protein Rv3425 from DNA segment RD11 of Mycobacterium tuberculosis in C57BL/6 mice" .MEDICAL MICROBIOLOGY AND IMMUNOLOGY 198,1(2009):5-11.

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