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Influences of doping mesoporous magnesium silicate on water absorption, drug release, degradability, apatite-mineralization and primary cells responses to calcium sulfate based bone cements 期刊论文

编号：

c21c95c0-4824-4ac8-be88-7ef5d120573b
作者：

Gu, Zhengrong(顾峥嵘)^[1,2]Wang, Sicheng^[1,3];Weng, Weizong^[1];Chen, Xiao^[1];Cao, Liehu^[1];Wei, Jie^[4];Shin, JungWoog^[5];Su, Jiacan^[1];
语种：

English
期刊：

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS ISSN：0928-4931 2017 年 75 卷 (620 - 628) ; JUN 1
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关键词：

Composite cements Mesoporous magnesium silicate Calcium sulfate Cytocompatibility
摘要：

In this study, composite cements containing mesoporous magnesium silicate (m-MS) and calcium sulfate (CS) were fabricated. The results revealed that the setting time of the m-MS/CS composite cements (m-MSC) slightly prolonged with the increase of m-MS content while the compressive strength suffered a little loss. The doping of m-MS improved the water absorption, drug release (vancomycin) and degradability of the m-MSC in Tris-HCl solution (pH = 7.4). In addition, addition of m-MS facilitated the apatite-mineralization of m-MSC in simulated body fluid (SBF), indicating good bioactivity. For cell cultural experiments, the results revealed that the m-MSC promoted the cells adhesion and proliferation, and improved the alkaline phosphatase (ALP) activity of MC3T3-E1 cells, revealing good cytocompatibility. It could be suggested that the m-MSC might be promising cements biomaterials for bone tissue regeneration. (C) 2017 Published by Elsevier B.V.
推荐引用方式
GB/T 7714：

Gu Zhengrong,Wang Sicheng,Weng Weizong, et al. Influences of doping mesoporous magnesium silicate on water absorption, drug release, degradability, apatite-mineralization and primary cells responses to calcium sulfate based bone cements [J].MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,2017,75:620-628.
APA：

Gu Zhengrong,Wang Sicheng,Weng Weizong,Chen Xiao,&Su Jiacan.(2017).Influences of doping mesoporous magnesium silicate on water absorption, drug release, degradability, apatite-mineralization and primary cells responses to calcium sulfate based bone cements .MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,75:620-628.
MLA：

Gu Zhengrong, et al. "Influences of doping mesoporous magnesium silicate on water absorption, drug release, degradability, apatite-mineralization and primary cells responses to calcium sulfate based bone cements" .MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 75(2017):620-628.

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