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Plasma metabolomics identified novel metabolites associated with risk of type 2 diabetes in two prospective cohorts of Chinese adults 期刊论文

编号：

c237e789-e791-4b38-8816-d9b8a0eee8b4
作者：

Qiu, Gaokun^[1,2,3] Zheng, Yan^[4,5] Wang, Hao^[1,2,3] Sun, Jie^[6] Ma, Hongxia^[6] Xiao, Yang^[1,2,3] Li, Yizhun^[1,2,3] Yuan, Yu^[1,2,3] Yang, Handong^[7] Li, Xiulou^[7] Min, Xinwen^[7] Zhang, Ce^[7] Xu, Chengwei^[7] Jiang, Yue^[6] Zhang, Xiaomin^[1,2,3] He, Meian^[1,2,3] Yang, Ming^[1,2,3] Hu, Zhibin^[6] Tang, Huiru^[8,9] Shen, Hongbing^[6] Hu, Frank B.^[4,5] Pan, An^[1,2,3] Wu, Tangchun^[1,2,3]
语种：

English
期刊：

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY ISSN：0300-5771 2016 年 45 卷 5 期 (1507 - 1516) ; OCT
收录：
关键词：

Type 2 diabetes targeted metabolomics nested case-control study Chinese population
摘要：

Background: Metabolomics studies in Caucasians have identified a number of novel metabolites in association with the risk of type 2 diabetes (T2D). However, few prospective metabolomic studies are available in Chinese populations. In the present study, we sought to identify novel metabolites consistently associated with incident T2D in two independent cohorts of Chinese adults. Methods: We performed targeted metabolomics (52 metabolites) of fasting plasma samples by liquid chromatography-mass spectrometry in two prospective case-control studies nested within the Dongfeng-Tongji (DFTJ) cohort and Jiangsu Non-communicable Disease (JSNCD) cohort. After following for 4.61 +/- 0.15 and 7.57 +/- 1.13 years, respectively, 1039 and 520 eligible participants developed incident T2D in these two cohorts, and controls were 1: 1 matched with cases by age (+/- 5 years) and sex. Multivariate conditional logistic regression models were constructed to identify metabolites associated with future T2D risk in both cohorts. Results: We identified four metabolites consistently associated with an increased risk of developing T2D in the two cohorts, including alanine, phenylalanine, tyrosine and palmitoylcarnitine. In the meta-analysis of two cohorts, the odds ratios (95% confidence intervals, CIs) comparing extreme quartiles were 1.79 (1.32-2.42) for alanine, 1.91 (1.41-2.60) for phenylalanine, 1.85 (1.37-2.48) for tyrosine and 1.63 (1.21-2.20) for palmitoylcarnitine ( all P-trend <= 0.01). Conclusions: We confirmed the association of alanine, phenylalanine and tyrosine with future T2D risk and further identified palmitoylcarnitine as a novel metabolic marker of incident T2D in two prospective cohorts of Chinese adults. Our findings might provide new aetiological insight into the development of T2D.
推荐引用方式
GB/T 7714：

Qiu Gaokun,Zheng Yan,Wang Hao, et al. Plasma metabolomics identified novel metabolites associated with risk of type 2 diabetes in two prospective cohorts of Chinese adults [J].INTERNATIONAL JOURNAL OF EPIDEMIOLOGY,2016,45(5):1507-1516.
APA：

Qiu Gaokun,Zheng Yan,Wang Hao,Sun Jie,&Wu Tangchun.(2016).Plasma metabolomics identified novel metabolites associated with risk of type 2 diabetes in two prospective cohorts of Chinese adults .INTERNATIONAL JOURNAL OF EPIDEMIOLOGY,45(5):1507-1516.
MLA：

Qiu Gaokun, et al. "Plasma metabolomics identified novel metabolites associated with risk of type 2 diabetes in two prospective cohorts of Chinese adults" .INTERNATIONAL JOURNAL OF EPIDEMIOLOGY 45,5(2016):1507-1516.

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