Background: We have previously defined a parkinsonism-related metabolic brain network in rhesus macaques using a high-resolution research positron emission tomography camera. This brief article reports a descriptive pilot study to assess the reproducibility of network activity and regional glucose metabolism in independent parkinsonian macaques using a clinical positron emission tomography/CT camera. Methods: [F-18]fluorodeoxyglucose PET scans were acquired longitudinally over 3 months in three drug-naive parkinsonian and three healthy control cynomolgus macaques. Group difference and test-retest stability in network activity and regional glucose metabolism were evaluated graphically, using all brain images from these macaques. Results: Comparing the parkinsonian macaques with the controls, network activity was elevated and remained stable over 3 months. Normalized glucose metabolism increased in putarnen/globus pallidus and sensorirnotor regions but decreased in posterior parietal cortices. Conclusions: Parkinsonism-related network activity can be reliably quantified in different macaques with a clinical positron emission tomography/CT scanner and is reproducible over a period typically employed in preclinical intervention studies. This measure can be a useful biomarker of disease process or drug effects in primate models of Parkinson's disease. (C) 2015 International Parkinson and Movement Disorder Society
[1]Feinstein Inst Med Res, Ctr Neurosci, Manhasset, NY 11030 USA.
[2]Univ Hlth Network, Toronto Western Hosp, Toronto Western Res Inst, Toronto, ON, Canada.
[3]Fudan Univ, PET Ctr Huashan Hosp, Shanghai 200433, Peoples R China.
[4]Univ Hlth Network, Toronto Western Hosp, Movement Disorder Clin, Toronto, ON, Canada.
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