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Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer 期刊论文 WOS高被引论文

编号：

c3ffcfee-c072-4203-aa62-00cb3f2fca4c
作者：

Yu, FaXing(余发星)#*^[1,2]Zhao, Bin^[3,4];Guan, KunLiang^[5,6];
语种：

英文
期刊：

CELL ISSN：0092-8674 2015 年 163 卷 4 期 (811 - 828) ; NOV 5
收录：
摘要：

Two decades of studies in multiple model organisms have established the Hippo pathway as a key regulator of organ size and tissue homeostasis. By inhibiting YAP and TAZ transcription co-activators, the Hippo pathway regulates cell proliferation, apoptosis, and stemness in response to a wide range of extracellular and intracellular signals, including cell-cell contact, cell polarity, mechanical cues, ligands of G-protein-coupled receptors, and cellular energy status. Dysregulation of the Hippo pathway exerts a significant impact on cancer development. Further investigation of the functions and regulatory mechanisms of this pathway will help uncovering the mystery of organ size control and identify new targets for cancer treatment.
推荐引用方式
GB/T 7714：

Yu Fa-Xing,Zhao Bin,Guan Kun-Liang, et al. Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer [J].CELL,2015,163(4):811-828.
APA：

Yu Fa-Xing,Zhao Bin,Guan Kun-Liang.(2015).Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer .CELL,163(4):811-828.
MLA：

Yu Fa-Xing, et al. "Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer" .CELL 163,4(2015):811-828.
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