Laboratory studies have suggested that perfluoroalkyl substances (PFASs) could affect fetal growth by disrupting estrogen homeostasis, but there are limited data for human. For this, 424 mother-infant pairs were selected from a cohort established in Hebei Province of North China in 2013. Two typical PFASs, perfluorooctyl sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA), and three typical estrogens, estrone (E-1), beta-estradiol (E-2), and estriol (E-3), were measured in cord serum. After adjusted for important covariates, serum PFOS was positively related to E-1 and E-3, but negatively related to E-2. Serum PFOA was positively related to serum E-1 and negatively related to head circumference at birth. Serum E-2 was negatively related to head circumference, body weight, and body length at birth and serum E-3 was positively related to body weight. Serum E-3 mediated the relationship between serum PFOS and body weight. There were sex-specific differences for the associations between PFOS/PFOA and estrogens/birth size. These findings suggested that exposure to PFASs could affect estrogen homeostasis and fetal growth during pregnancy and that estrogens might mediate the association between exposure to PFASs and fetal growth. (C) 2019 Elsevier Ltd. All rights reserved.
[1]Fudan Univ, Sch Publ Hlth, Minist Educ, Key Lab Publ Hlth Safety, Shanghai 200032, Peoples R China;
[2]Univ Manitoba, Dept Anim Sci, Dept Physiol & Pathophysiol, Winnipeg, MB R3T 2N2, Canada;
[3]Maternal & Child Hlth Care Hosp Tangshan Municipa, Tangshan 063000, Hebei, Peoples R China;
[4]Univ Ottawa, Fac Med, Sch Epidemiol & Publ Hlth, Ottawa, ON K1G5Z3, Canada
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