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Quantitative assessment of liver fibrosis (qFibrosis) reveals precise outcomes in Ishak "stable" patients on anti-HBV therapy 期刊论文

编号：

c4773559-6a2f-4169-bb69-ce6d439ecc3d
作者：

Sun, Yameng^[1];Zhou, Jialing^[1];Wu, Xiaoning^[1];Chen, Yongpeng^[2];Piao, Hongxin^[3];Lu, Lungen^[4];Ding, Huiguo^[5];Nan, Yuemin^[6];Jiang, Wei(蒋炜)^[7]Wang, Tailing^[8];Liu, Hui^[9];Ou, Xiaojuan^[1];Wee, Aileen^[10];Theise, Neil D.^[11];Jia, Jidong^[1];You, Hong^[1];
语种：

英文
期刊：

SCIENTIFIC REPORTS ISSN：2045-2322 2018 年 8 卷 ; FEB 14
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摘要：

Current widely used semiquantitative histological assessment methods are insensitive to identify subtle changes of liver fibrosis. Therefore, to precisely assess therapeutic efficacy on chronic hepatitis B (CHB), we explored the utility of qFibrosis (a fully-quantitative morphometric method employing second harmonic generation/two photon excitation fluorescence) in liver fibrosis evaluation. Fibrosis changes were evaluated by Ishak fibrosis scoring and qFibrosis in CHB patients with paired liver biopsies before and after 78 weeks' antiviral therapy. A total of 162 patients with qualified paired biopsies were enrolled. Ishak fibrosis scoring revealed that 42.6% (69/162) of the patients achieved fibrosis regression (>= 1-point decrease), 51.9% (84/162) remained stable, and 5.5% (9/162) showed progression (>= 1-point increase). qFibrosis showed similar trends in the groups of regression and progression patients as evaluated by Ishak. However, in Ishak stable patients, qFibrosis revealed hitherto undetected changes, allowing for further subcategorization into regression ("Regression by qFibrosis"; 40/84, 47.6%), stable (29/84, 34.5%), and progression ("Progression by qFibrosis"; 15/84, 17.9%) groups. These newly fine-tuned categories were supported by changes of morphological parameters of fibrosis, collagen percentage area, and liver stiffness measurements. In conclusion, qFibrosis can be used to quantitatively identify subtle changes of liver fibrosis in CHB patients after antiviral therapy.
推荐引用方式
GB/T 7714：

Sun Yameng,Zhou Jialing,Wu Xiaoning, et al. Quantitative assessment of liver fibrosis (qFibrosis) reveals precise outcomes in Ishak "stable" patients on anti-HBV therapy [J].SCIENTIFIC REPORTS,2018,8.
APA：

Sun Yameng,Zhou Jialing,Wu Xiaoning,Chen Yongpeng,&You Hong.(2018).Quantitative assessment of liver fibrosis (qFibrosis) reveals precise outcomes in Ishak "stable" patients on anti-HBV therapy .SCIENTIFIC REPORTS,8.
MLA：

Sun Yameng, et al. "Quantitative assessment of liver fibrosis (qFibrosis) reveals precise outcomes in Ishak "stable" patients on anti-HBV therapy" .SCIENTIFIC REPORTS 8(2018).
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