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In vitro Biocompatibility of a Platinum-Electrode Embedded Photosensitive Polyimide (Durimide) Retinal Prosthesis 期刊论文

编号：

c4aa19e0-7602-4163-9570-c61f8db38277
作者：

Liu, Wenjia^[1] Song, ZhengYu^[1] Mo, Yanan^[1] Wang, Weijun^[1] Sui, Xiaohong^[3] Gong, Yuanyuan^[1] Jiang, Yuan^[1] Zhang, Lei Huang, Jiannan Gu, Qing^[1] Li, Gang^[4] Zhou, Chuanqing^[3] Yu, Zhang^[5] Ren, Qiushi^[2] Sun, Xiaodong^[1] Wang, Fenghua^[1]
语种：

英文
期刊：

CURRENT EYE RESEARCH ISSN：0271-3683 2012 年 37 卷 11 期 (1036 - 1044) ; NOV
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关键词：

Biocompatibility Retinal prosthesis Cytotoxicity Durimide
摘要：

Purpose: The photosensitive polyimide film, Durimide, is a common component of retinal prostheses; however, retinal cell response to Durimide has not been effectively studied This work assessed the in vitro biocompatibility of a retinal prosthesis containing platinum-electrode embedded Durimide film.
Materials and methods: Biocompatibility evaluation assessed cytotoxicity, attachment, and proliferation of two cell lines: a human retinal pigmented epithelium cell line (CRL) and a rhesus monkey choroid-retinal endothelial cell line (RF/6A). Cells were cultured with the platinum-electrode embedded Durimide film, with tissue-culture treated polystyrene plates (TCPS) used as a control substrate for cell growth. The effect of a Durimide-exposed medium on cell apoptosis and life cycle was assessed using flow cytometry (FCM).
Results: The indirect cytotoxicity evaluation revealed no toxic effect of the prosthesis on cells. The attachment and proliferation of CRL and RF/6A cells cultured with the Durimide prostheses showed no significant differences to the control. The FCM experiments demonstrated a liquid medium exposed to the prosthesis had no effects on apoptosis or cell life cycle in comparison with the control (p > 0.05).
Conclusions: The results demonstrate that Durimide has good biocompatibility with retinal cell lines CRL and RF/6A. In conclusion, while further in vitro and in vivo studies are required to clarify long-term effects, Durimide is indicated as a promising material with suitable biocompatibility for retinal implants.
推荐引用方式
GB/T 7714：

Liu Wenjia,Song ZhengYu,Mo Yanan, et al. In vitro Biocompatibility of a Platinum-Electrode Embedded Photosensitive Polyimide (Durimide) Retinal Prosthesis [J].CURRENT EYE RESEARCH,2012,37(11):1036-1044.
APA：

Liu Wenjia,Song ZhengYu,Mo Yanan,Wang Weijun,&Wang Fenghua.(2012).In vitro Biocompatibility of a Platinum-Electrode Embedded Photosensitive Polyimide (Durimide) Retinal Prosthesis .CURRENT EYE RESEARCH,37(11):1036-1044.
MLA：

Liu Wenjia, et al. "In vitro Biocompatibility of a Platinum-Electrode Embedded Photosensitive Polyimide (Durimide) Retinal Prosthesis" .CURRENT EYE RESEARCH 37,11(2012):1036-1044.
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