首页 / 院系成果 / 成果详情页

RNA interference of hypoxia-inducible factor-1 alpha improves the effects of transcatheter arterial embolization in rat liver tumors 期刊论文

编号：

c60f437c-936e-4093-825e-0298a71470d5
作者：

Chen, ChengShi^[1];Wang, JianHua^[1];Liu, Rong^[1];Qian, Sheng(钱晟)^[1]
语种：

English
期刊：

TUMOR BIOLOGY ISSN：1010-4283 2012 年 33 卷 4 期 (1095 - 1103) ; AUG
收录：
关键词：

Transcatheter arterial embolization Hepatocellular carcinoma Hypoxia-inducible factor-1alpha RNA interference
摘要：

Transcatheter arterial embolization (TAE) and transcatheter arterial chemoembolization are widely used palliative treatments for patients with nonsurgical hepatocellular carcinoma. TAE has been shown to increase levels of hypoxia-inducible factor-1 alpha (HIF-1 alpha) in tumors. In this study, we investigated whether RNA interference (RNAi) of HIF-1 alpha could improve the efficacy of TAE to treat HCC. Four treatment groups were assessed using a rat allograft model of HCC: RNAi of HIF-1 alpha combined with TAE, RNAi of HIF-1 alpha only, TAE only, and a control group. Rats were treated by TAE by retrograde placement of a microcatheter into the gastroduodenal artery. The results demonstrated that the RNAi of HIF-1 alpha visibly reduced the expression of HIF-1 alpha and vascular endothelial growth factor, suppressed tumor angiogenesis, and attenuated metastasis, which were all enhanced by TAE. The RNAi of HIF-1 alpha synergized with TAE to significantly inhibit tumor growth. In conclusion, RNAi of HIF-1 alpha augmented the therapeutic effects of TAE and diminished its undesirable effects.
推荐引用方式
GB/T 7714：

Chen ChengShi,Wang JianHua,Liu Rong, et al. RNA interference of hypoxia-inducible factor-1 alpha improves the effects of transcatheter arterial embolization in rat liver tumors [J].TUMOR BIOLOGY,2012,33(4):1095-1103.
APA：

Chen ChengShi,Wang JianHua,Liu Rong,Qian Sheng.(2012).RNA interference of hypoxia-inducible factor-1 alpha improves the effects of transcatheter arterial embolization in rat liver tumors .TUMOR BIOLOGY,33(4):1095-1103.
MLA：

Chen ChengShi, et al. "RNA interference of hypoxia-inducible factor-1 alpha improves the effects of transcatheter arterial embolization in rat liver tumors" .TUMOR BIOLOGY 33,4(2012):1095-1103.

浏览次数：4  下载次数：0

分享到：

浏览次数：4

下载次数：0

打印次数：0