首页 / 院系成果 / 成果详情页

Reduction of HIP2 expression causes motor function impairment and increased vulnerability to dopaminergic degeneration in Parkinson's disease models 期刊论文

编号：

c626e15a-5d31-4271-8ecc-47e6114af02c
作者：

Su, Jinlin^[1,2,3];Huang, Pei^[4,5];Qin, Meiling^[1,2];Lu, Qingqing^[1,2,3];Sang, Xiao^[1,2,3];Cai, Yijun^[1,2,6];Wang, Ying^[7];Liu, Fubing^[8];Wu, Rong^[9];Wang, Xiaoping^[9];Jiang, Xiaoxing(姜晓幸)^[8]Wang, Jian(王坚)^[7]Sun, Qiang^[1,2,6];Chen, Shengdi^[4,5];Xu, Jin^[1,2];
语种：

English
期刊：

CELL DEATH & DISEASE ISSN：2041-4889 2018 年 9 卷 ; OCT 3
收录：
摘要：

Huntingtin interaction protein 2 (HIP2) is an E2 ubiquitin-conjugating enzyme associated with neurodegenerative diseases, and HIP2 mRNA has been implicated as a potential blood biomarker for Parkinson's disease (PD). However, it is unclear whether the alteration of HIP2 expression may contribute to the development of PD, and whether the change of HIP2 in blood could reflect its expression in the brain or motor functions in PD patients. In this study, we established a mouse line with HIP2 haploinsufficiency. The reduction of the HIP2 expression led to spontaneous motor function impairment and dopaminergic neuronal loss. Furthermore, HIP2 haploinsufficiency increased the susceptibility of mice to 6-hydroxydopamine (6-OHDA) and caused severe loss of dopaminergic neurons. Interestingly, in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model for PD, we observed concurrent, highly correlated decrease of HIP2 expression in the brain and in the blood. Using blood samples from more than 300 patients, we validated the decreased HIP2 mRNA in PD patients, including de novo patients. Finally, in a 1-year, 20-patient study, we observed reversed blood HIP2 mRNA levels accompanying improved motor and overall daily functions in 75% of the PD patients with instructed Tai Chi training. Therefore, our in vivo studies have indicated HIP2 insufficiency as a contributing factor for PD, and functionally validated blood HIP2 as a useful and reversible biomarker for PD.
推荐引用方式
GB/T 7714：

Su Jinlin,Huang Pei,Qin Meiling, et al. Reduction of HIP2 expression causes motor function impairment and increased vulnerability to dopaminergic degeneration in Parkinson's disease models [J].CELL DEATH & DISEASE,2018,9.
APA：

Su Jinlin,Huang Pei,Qin Meiling,Lu Qingqing,&Xu Jin.(2018).Reduction of HIP2 expression causes motor function impairment and increased vulnerability to dopaminergic degeneration in Parkinson's disease models .CELL DEATH & DISEASE,9.
MLA：

Su Jinlin, et al. "Reduction of HIP2 expression causes motor function impairment and increased vulnerability to dopaminergic degeneration in Parkinson's disease models" .CELL DEATH & DISEASE 9(2018).

浏览次数：5  下载次数：0

分享到：

浏览次数：5

下载次数：0

打印次数：0