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The predictive role of ADC values in prostate cancer patients treated with carbon-ion radiotherapy: initial clinical experience at Shanghai Proton and Heavy Ion Center (SPHIC) 期刊论文

编号：

c630860e-1fa5-4627-a1df-28ed7d2d21cf
作者：

Qi, WeiXiang^[1] Zhang, Qing^[1] Li, Ping^[1] Zhang, XiaoMeng^[3] Zhang, GuangYuan^[2] Wu, Bin^[2] Lu, Jiade J.^[1] Jiang, GuoLiang^[1] Fu, Shen^[3]
语种：

English
期刊：

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY ISSN：0171-5216 2016 年 142 卷 6 期 (1361 - 1367) ; JUN
收录：
关键词：

Prostate cancer Carbon-ion radiotherapy Diffusion-weighted MRI Prostate-specific antigen
摘要：

The aim of our study was to investigate the predictive role of apparent diffusion coefficient (ADC) values in evaluating for therapeutic changes from carbon-ion radiotherapy (CIRT) in prostate cancer patients. Thirty-one patients with prostate cancer treated with CIRT were enrolled in this retrospective study. Diffusion-weighted imaging (DWI) at 3-T was performed before and after CIRT. Before and after treatment, ADC values were measured in the tumors and in the benign tissues of the prostate, and serum prostate-specific antigen (PSA) levels were also assessed. We divided the patients into two groups: PSA response (PSA declines a parts per thousand yen50 %) and non-PSA response group (PSA declines < 50 %). After CIRT treatment, the mean ADC value of the tumors (1.23 x 10(-3)mm(2)/s) was significantly increased as compared with the pretreatment value (1.07 x 10(-3)mm(2)/s) (p < 0.001), whereas the ADC values of the benign tissues after treatment did not significantly increase compared with the pretreatment values (p = 0.235). The mean PSA level was significantly reduced from 2.027 ng/mL before treatment to 0.822 ng/mL, respectively, after treatment (p = 0.0063). The mean of ADC changes in PSA response group before and after CIRT was significantly higher than that in non-PSA response group (a dagger ADC value: 0.217 vs 0.097 x 10(-3)mm(2)/s, p = 0.0229), and the rate of patients with PSA response was higher in the high a dagger ADC group (a dagger ADC a parts per thousand yen 0.10) than in the low a dagger ADC group (a dagger ADC < 0.10) (72.7 and 33.3 %, respectively), but marginally significant (p = 0.056). Additionally, the baseline tumor ADC values revealed a negative correlation with changes in PSA levels after treatment (correlation coefficient, rho = -0.524; p = 0.0025). Our preliminary results suggest that ADC vales measurement may be a useful imaging biomarker for prediction and early assessment of therapeutic response of prostate cancer to CIRT.
推荐引用方式
GB/T 7714：

Qi Wei-Xiang,Zhang Qing,Li Ping, et al. The predictive role of ADC values in prostate cancer patients treated with carbon-ion radiotherapy: initial clinical experience at Shanghai Proton and Heavy Ion Center (SPHIC) [J].JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY,2016,142(6):1361-1367.
APA：

Qi Wei-Xiang,Zhang Qing,Li Ping,Zhang Xiao-Meng,&Fu Shen.(2016).The predictive role of ADC values in prostate cancer patients treated with carbon-ion radiotherapy: initial clinical experience at Shanghai Proton and Heavy Ion Center (SPHIC) .JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY,142(6):1361-1367.
MLA：

Qi Wei-Xiang, et al. "The predictive role of ADC values in prostate cancer patients treated with carbon-ion radiotherapy: initial clinical experience at Shanghai Proton and Heavy Ion Center (SPHIC)" .JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 142,6(2016):1361-1367.

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