Objective: To investigate potential associations between body mass index (BMI) and head and neck cancer (HNC) risk in an East Asian population.
Methods: We conducted a hospital-based multicenter case-control study in East Asia including 921 cases and 806 controls. We estimated the odds ratios (ORs) and 95% confidence intervals (95% CI) for HNC risks by using logistic regression, adjusting on potential confounders.
Results: Compared to normal BMI at interview (18.5- < 25 kg/m(2)), being underweight (BMI < 18.5 kg/m(2)) was associated with a higher HNC risk (OR = 2.71, 95% CI 1.40-5.26). Additionally, obesity (BMI > 30 kg/m(2)) was associated with a lower HNC risk (OR = 0.30, 95% CI 0.16-0.57). Being underweight at age 20 was also associated with an increased risk of HNC. However, being underweight at 5 years or 2 years before interview was not associated with a higher risk of HNC.
Conclusion: We observed an inverse association between BMI and HNC risk, which is consistent with previous studies in other geographic regions. Being underweight at age 20 was also associated with a higher risk of HNC, suggesting that reverse causality was not the main source of the association.
[1]Univ Utah, Sch Med, Div Publ Hlth, Dept Family & Prevent Med, Salt Lake City, UT 84112 USA;
[2]Huntsman Canc Inst, Salt Lake City, UT USA;
[3]Icahn Sch Med Mt Sinai, Dept Prevent Med, New York, NY 10029 USA;
[4]Acad Sinica, Genom Res Ctr, Taipei, Taiwan;
[5]Natl Taiwan Univ, Grad Inst Epidemiol & Prevent Med, Taipei, Taiwan;
[6]Natl Taiwan Univ Hosp, Dept Otolaryngol, Taipei, Taiwan;
[7]Sichuan Univ, West China Sch Publ Hlth, Dept Epidemiol & Biostat, Chengdu, Sichuan, Peoples R China;
[8]Sichuan Univ, West China Hosp Stomatol, Dept Oral Surg, Chengdu, Sichuan, Peoples R China;
[9]Nanjing Med Univ, Jiangsu Key Lab Canc Biomarkers Prevent & Treanne, Collaborat Innovat Ctr Canc Personalized Med, Sch Publ Hlth,Dept Epidemiol & Biostat, Nanjing, Jiangsu, Peoples R China;
[10]Fujian Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Fuzhou, Fujian, Peoples R China;
[11]Fudan Univ, Dept Head & Neck Surg, Shanghai Canc Ctr, Shanghai, Peoples R China;
[12]Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai, Peoples R China;
[13]Fudan Univ, Dept Pathol, Shanghai Canc Ctr, Shanghai, Peoples R China;
[14]China Med Univ, Sch Publ Hlth, Dept Epidemiol, Shenyang, Liaoning, Peoples R China;
[15]Henan Canc Hosp, Dept Head & Neck Oncol, Zhengzhou, Henan, Peoples R China;
[16]Nagoya City Univ, Grad Sch Med Sci, Dept Otorhinolaryngol Head & Neck Surg, Nagoya, Aichi, Japan;
[17]Icahn Sch Med Mt Sinai, Tisch Canc Inst, New York, NY 10029 USA;
[18]UCLA, Fielding Sch Publ Hlth, Dept Epidemiol, Los Angeles, CA USA;
[19]UCLA, Ctr Environm Genom, Fielding Sch Publ Hlth, Los Angeles, CA USA;
[20]Canc Inst & Hosp, Natl Off Canc Prevent & Control, Beijing, Peoples R China;
[21]Chinese Acad Med Sci, Beijing, Peoples R China
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