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MYBPH inhibits vascular smooth muscle cell migration and attenuates neointimal hyperplasia in a rat carotid balloon-injury model 期刊论文

编号：

c6578d9a-012b-4e53-a000-0137733da4af
作者：

Zhu, Ting(竺挺)^[1]He, Yi^[2];Yang, Jue(杨珏)^[1]Fu, Weiguo(符伟国)^[1]Xu, Xin(徐欣)*^[1]Si, Yi(司逸)*^[1]
语种：

English
期刊：

EXPERIMENTAL CELL RESEARCH ISSN：0014-4827 2017 年 359 卷 1 期 (154 - 162) ; OCT 1
收录：
关键词：

MYBPH Vascular smooth muscle cell Migration ROCK1 Neointima formation
摘要：

Vascular smooth muscle cell (VSMC) migration is implicated in restenosis. Myosin binding protein H (MYBPH) is capable of reducing cell motility and metastasis. In this study, we sought to determine whether MYBPH is involved in VSMC migration and neointima formation in response to vascular injury. To determine the expression of MYBPH in injured artery, we used a standard rat carotid artery balloon-injury model. In vivo studies have demonstrated that MYBPH is upregulated after vascular injury. VSMCs treated with platelet derived growth factor (PDGF)-BB displayed increased MYBPH mRNA and protein levels. PDGF-induced VSMC migration was inhibited by adenovirus-mediated expression of MYBPH whereas it was enhanced by small interfering RNA knockdown of MYBPH. The activation of ROCK1 was repressed by MYBPH. Luminal delivery of MYBPH adenovirus to carotid arteries decreased neointimal hyperplasia in vivo. MYBPH may, therefore, serve as a novel therapeutic target for postangioplasty restenosis.
推荐引用方式
GB/T 7714：

Zhu Ting,He Yi,Yang Jue, et al. MYBPH inhibits vascular smooth muscle cell migration and attenuates neointimal hyperplasia in a rat carotid balloon-injury model [J].EXPERIMENTAL CELL RESEARCH,2017,359(1):154-162.
APA：

Zhu Ting,He Yi,Yang Jue,Fu Weiguo,&Si Yi.(2017).MYBPH inhibits vascular smooth muscle cell migration and attenuates neointimal hyperplasia in a rat carotid balloon-injury model .EXPERIMENTAL CELL RESEARCH,359(1):154-162.
MLA：

Zhu Ting, et al. "MYBPH inhibits vascular smooth muscle cell migration and attenuates neointimal hyperplasia in a rat carotid balloon-injury model" .EXPERIMENTAL CELL RESEARCH 359,1(2017):154-162.

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