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Characterization of Coronary Flow Reserve and Left Ventricular Remodeling in a Mouse Model of Chronic Aortic Regurgitation With Carvedilol Intervention 期刊论文

编号：

c74c1bf3-2c8f-43bb-aa73-952720c97472
作者：

Wang, Xiangfei(王翔飞)#^[1]Wu, Jian(吴剑)^[1,2]Zhu, Dan^[3];You, Jieyun(游洁芸)^[1]Zou, Yunzeng(邹云增)^[1]Qian, Juying(钱菊英)^[1]Ge, Junbo(葛均波)*^[1]
语种：

English
期刊：

JOURNAL OF ULTRASOUND IN MEDICINE ISSN：0278-4297 2015 年 34 卷 3 期 (483 - 493) ; MAR 1
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关键词：

aortic regurgitation carvedilol coronary flow reserve echocardiography left ventricular remodeling
摘要：

Objectives-We hypothesized that left ventricular (LV) remodeling might be exaggerated by an impaired coronary flow reserve in mice with chronic severe aortic regurgitation, and carvedilol, a beta-adrenoceptor blocker, could regress the course. Methods-Severe aortic regurgitation was induced by retrograde puncture of the aortic valve leaflets under sonographic guidance in 12-week-old male C57BL/6J mice. Four weeks after regurgitation, the mice were treated with carvedilol (30 mg/kg/d) or not treated (control). Before and 4 weeks after carvedilol treatment, the coronary flow reserve and LV structure and function were evaluated by echocardiography. Cardiomyocytes and fibrosis were validated by histologic analysis. Results-Four-week aortic regurgitation caused a decreased LV ejection fraction and an increased LV end-systolic volume index. Regurgitation also impaired the coronary flow reserve due to an increase in the basal coronary peak diastolic velocity and velocity-time integral combined with the absence of substantial changes in the hyperemic coronary peak diastolic velocity and velocity-time integral. Four more weeks of regurgitation further deteriorated LV remodeling and coronary perfusion in the control group. In contrast, the carvedilol-treated group showed attenuated LV remodeling and a higher coronary flow reserve by decreasing the basal peak diastolic velocity and velocity-time integral without substantial changes in the hyperemic peak diastolic velocity and velocity-time integral. The coronary flow reserve and its pretreatment versus posttreatment difference were positively correlated with the pretreatment versus posttreatment LV ejection fraction and end-systolic volume index differences. In the carvedilol-treated group, subendocardial fibrosis was significantly reduced (P < .05), and the cardiomyocyte cross-sectional area tended to be smaller. Conclusions-In mice with chronic severe aortic regurgitation, carvedilol therapy significantly improves the impaired coronary flow reserve and sufficiently attenuates adverse LV remodeling. Sustained coronary flow reserve impairment indicates progressive LV remodeling.
推荐引用方式
GB/T 7714：

Wang Xiangfei,Wu Jian,Zhu Dan, et al. Characterization of Coronary Flow Reserve and Left Ventricular Remodeling in a Mouse Model of Chronic Aortic Regurgitation With Carvedilol Intervention [J].JOURNAL OF ULTRASOUND IN MEDICINE,2015,34(3):483-493.
APA：

Wang Xiangfei,Wu Jian,Zhu Dan,You Jieyun,&Ge Junbo.(2015).Characterization of Coronary Flow Reserve and Left Ventricular Remodeling in a Mouse Model of Chronic Aortic Regurgitation With Carvedilol Intervention .JOURNAL OF ULTRASOUND IN MEDICINE,34(3):483-493.
MLA：

Wang Xiangfei, et al. "Characterization of Coronary Flow Reserve and Left Ventricular Remodeling in a Mouse Model of Chronic Aortic Regurgitation With Carvedilol Intervention" .JOURNAL OF ULTRASOUND IN MEDICINE 34,3(2015):483-493.

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