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In vivo evaluation of an in-situ hydrogel system for vaginal administration  期刊论文  

  • 编号:
    c7f508ff-ac38-4350-8ac2-43b4954806ef
  • 作者:
    Li, Chenxi[2];Han, Cong[1];Zhu, Yan[3];Lu, Weiyue(陆伟跃)[1,4]Li, Qiuhong[2];Liu, Yu(刘瑜)*[1,4]
  • 语种:
    English
  • 期刊:
    PHARMAZIE ISSN:0031-7144 2014 年 69 卷 6 期 (458 - 460) ; JUN
  • 收录:
  • 摘要:

    The vaginal retention and local irritation of a carrageenan, poloxamer 407 and carbopol-based thermosensitive hydrogel system for vaginal drug delivery was assessed. Results showed that the residence of hydrogel in the mouse vagina following intravaginal administration was prolonged by carrageenan and further prolonged by the addition of a mucoadhesive component (carbopol). The optimal hydrogel formulation was proven to be safe for vaginal use in rabbits.

  • 推荐引用方式
    GB/T 7714:
    Li Chenxi,Han Cong,Zhu Yan, et al. In vivo evaluation of an in-situ hydrogel system for vaginal administration [J].PHARMAZIE,2014,69(6):458-460.
  • APA:
    Li Chenxi,Han Cong,Zhu Yan,Lu Weiyue,&Liu Yu.(2014).In vivo evaluation of an in-situ hydrogel system for vaginal administration .PHARMAZIE,69(6):458-460.
  • MLA:
    Li Chenxi, et al. "In vivo evaluation of an in-situ hydrogel system for vaginal administration" .PHARMAZIE 69,6(2014):458-460.
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