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Validation of the Oxford classification of IgA nephropathy for pediatric patients from China 期刊论文

编号：

cb298434-a390-4fb0-a13c-20b02b9bb581
作者：

Le, Weibo^[2];Zeng, CaiHong^[2];Liu, Zhangsuo^[3];Liu, Dong^[3];Yang, Qing^[4];Lin, RuiXia^[4];Xia, ZhengKun^[5];Fan, ZhongMin^[5];Zhu, Guanghua^[6];Wu, Ying^[6];Xu, Hong(徐虹)^[7]Zhai, Yihui^[7];Ding, Ying^[8];Yang, Xiaoqing^[8];Liang, Shaoshan^[2];Chen, Hao^[2];Xu, Feng^[2];Huang, Qian^[2];Shen, Hongbing^[9,10];Wang, Jianming^[9,10];Fogo, Agnes B.^[1];Liu, ZhiHong^[2];
语种：

English
期刊：

BMC NEPHROLOGY ISSN：1471-2369 2012 年 13 卷 ; NOV 27
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关键词：

Glomerulonephritis IgA nephropathy Oxford classification Children Pediatrics
摘要：

Background: The Oxford classification of IgA nephropathy (IgAN) provides a useful tool for prediction of renal prognosis. However, the application of this classification in children with IgAN needs validation in different patient populations. Methods: A total of 218 children with IgAN from 7 renal centers in China were enrolled. The inclusion criteria was similar to the original Oxford study. Results: There were 98 patients (45%) with mesangial proliferation (M1), 51 patients (23%) with endocapillary proliferation (E1), 136 patients (62%) with segmental sclerosis/adhesion lesion (S1), 13 patients (6%) with moderate tubulointerstitial fibrosis (T1 26-50% of cortex scarred), and only 2 patients (1%) with severe tubulointerstitial fibrosis (T2, >50% of cortex scarred). During a median follow-up duration of 56 months, 24 children (12.4%) developed ESRD or 50% decline in renal function. In univariate COX analysis, we found that tubular atrophy/interstitial fibrosis (HR 4.3, 95%CI 1.8-10.5, P < 0.001) and segmental glomerulosclerosis (HR 9.2 1.2-68.6, P = 0.03) were significant predictors of renal outcome. However, mesangial hypercellularity, endocapillary proliferation, crescents, and necrosis were not associated with renal prognosis. In the multivariate COX regression model, none of these pathologic lesions were shown to be independent risk factors of unfavorable renal outcome except for tubular atrophy/interstitial fibrosis (HR 2.9, 95% CI 1.0-7.9 P = 0.04). Conclusions: We confirmed tubular atrophy/interstitial fibrosis was the only feature independently associated with renal outcomes in Chinese children with IgAN.
推荐引用方式
GB/T 7714：

Le Weibo,Zeng Cai-Hong,Liu Zhangsuo, et al. Validation of the Oxford classification of IgA nephropathy for pediatric patients from China [J].BMC NEPHROLOGY,2012,13.
APA：

Le Weibo,Zeng Cai-Hong,Liu Zhangsuo,Liu Dong,&Liu Zhi-Hong.(2012).Validation of the Oxford classification of IgA nephropathy for pediatric patients from China .BMC NEPHROLOGY,13.
MLA：

Le Weibo, et al. "Validation of the Oxford classification of IgA nephropathy for pediatric patients from China" .BMC NEPHROLOGY 13(2012).

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